Food and Nutrition Sciences

Volume 4, Issue 11 (November 2013)

ISSN Print: 2157-944X   ISSN Online: 2157-9458

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Effects of Dietary Citric Acid on Metabolic Indicators and Gene Expression in the Skeletal Muscles of Fasted Mice

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DOI: 10.4236/fns.2013.411145    5,809 Downloads   7,710 Views   Citations

ABSTRACT

Citric acid is recognized and utilized as a dietary supplement for its ability to eliminate fatigue. However, the molecular and cellular mechanism underlying this effect has not been elucidated. This study investigated the effect of intragastric citric acid administration on the energy metabolism and gene expression in the skeletal muscles of mice that had been fasted without exercise, using biochemical analyses of metabolic indicators and DNA microarrays. Expression of the genes involved in the glycolysis, tricarboxylic acid cycle and β-oxidation of fatty acids were not affected by citric acid administration. However, citric acid increased the level of blood glucose and expression of the phosphoenolpyruvate carboxykinase gene. These results indicate that citric acid ingestion may eliminate fatigue by promoting gluconeogenesis.

Cite this paper

Y. Hara and N. Watanabe, "Effects of Dietary Citric Acid on Metabolic Indicators and Gene Expression in the Skeletal Muscles of Fasted Mice," Food and Nutrition Sciences, Vol. 4 No. 11, 2013, pp. 1114-1119. doi: 10.4236/fns.2013.411145.

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