Pharmacology & Pharmacy

Volume 4, Issue 6 (September 2013)

ISSN Print: 2157-9423   ISSN Online: 2157-9431

Google-based Impact Factor: 0.69  Citations  h5-index & Ranking

Influence of the Meal and Genotype of CYP2C19 on the Pharmacokinetics of Proton Pump Inhibitors in Healthy Japanese Subjects

HTML  Download Download as PDF (Size: 664KB)  PP. 502-509  
DOI: 10.4236/pp.2013.46073    3,225 Downloads   4,923 Views  Citations

ABSTRACT

Objectives: To evaluate the influence of meals on the pharmacokinetics of omeprazole and rabeprazole and to investigate these PPIs with reference to CYP2C19 genotypes in healthy Japanese men. Methods: This was a randomized, open label, four-way crossover study. Twelve healthy Japanese male volunteers received a single oral dose of either 20 mg omeprazole or 10 mg rabeprazole, in the fasted state and after a standardized breakfast. Results: Between the administration of omeprazole in the fasted state and after breakfast, there were no significant differences in Cmax, AUC, Tmax, and half-life. Between the administration of rabeprazole in the fasted state and after breakfast, there were no significant differences in Cmax, AUC and half-life, whereas the Tmax of rabeprazole after breakfast was significantly delayed (2.8 ± 1.0 vs 5.3 ± 1.8 h, respectively; p = 0.006). PMs demonstrated the highest Cmax and AUC after drug intake under the fasting state and after breakfast, and homo EMs showed a significantly delayed Tmax. Conclusion: When a single dose of either PPI was administered, the pharmacokinetics of omeprazole was not affected by the meal, whereas the Tmax of rabeprazole after the meal was significantly delayed.

Share and Cite:

H. Shinkai, T. Koike, M. Shimada, K. Nakagawa, K. Iijima, Y. Matsumoto, M. Maekawa, N. Mano and T. Shimosegawa, "Influence of the Meal and Genotype of CYP2C19 on the Pharmacokinetics of Proton Pump Inhibitors in Healthy Japanese Subjects," Pharmacology & Pharmacy, Vol. 4 No. 6, 2013, pp. 502-509. doi: 10.4236/pp.2013.46073.

Copyright © 2021 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.