World Journal of Cardiovascular Diseases

Volume 3, Issue 5 (August 2013)

ISSN Print: 2164-5329   ISSN Online: 2164-5337

Google-based Impact Factor: 0.45  Citations  

Endothelin A-receptors and the coronary circulation

HTML  Download Download as PDF (Size: 267KB)  PP. 371-376  
DOI: 10.4236/wjcd.2013.35057    3,081 Downloads   4,399 Views  


We review the role of endothelin (ET) A-receptors (R) on the coronary circulation. ET-1 maintains the normal coronary artery tone. ET-1 plasma levels are increased during and after coronary angioplasty and this increase is related to myocardial ischaemia rather than to mechanical artery injury. ETAR antagonists inhibit coronary artery vasoconstriction induced by ET release after coronary angioplasty in humans. ET promotes neointimal formation and ETAR antagonism has been shown to inhibit restenosis after angioplasty in the animal model but not in humans. ETAR blockade increases coronary blood flow, dilates distal coronary arterial segments and decreases coronary vascular resistance. Coronary collaterals are less sensitive than other coronary vessels to ET-1. ETAR blockade decreases collateral blood flow and, consequently, perfusion of the ischemic myocardium.

Share and Cite:

Polymeropoulos, E. , Valenti, M. and Kyriakides, Z. (2013) Endothelin A-receptors and the coronary circulation. World Journal of Cardiovascular Diseases, 3, 371-376. doi: 10.4236/wjcd.2013.35057.

Cited by

No relevant information.

Copyright © 2023 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.