Biological sources of L-DOPA: An alternative approach - Advances in Parkinson's Disease

APD > Vol.2 No.3, August 2013

Advances in Parkinson's Disease

Volume 2, Issue 3 (August 2013)

ISSN Print: 2169-9712 ISSN Online: 2169-9720

Google-based Impact Factor: 1.36 Citations

Biological sources of L-DOPA: An alternative approach ()

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Download as PDF (Size: 256KB) PP. 81-87

DOI: 10.4236/apd.2013.23016 17,761 Downloads 31,797 Views Citations

Author(s)

Sushama A. Patil, Onkar A. Apine, Shripad N. Surwase, Jyoti P. Jadhav

Affiliation(s)

Department of Biotechnology, Shivaji University, Kolhapur, India.
Department of Microbiology, Shivaji University, Kolhapur, India.

ABSTRACT

Parkinson’s disease was first formally identified by British physician James Parkinson in 1817 as “The Shaking Palsy”. L-DOPA (3,4-dihydroxy-phenyl-L-alanine) has been considered as a gold-standard treatment for Parkinson’s disease. The world market for L-DOPA is about 250 t/year and the total market volume is about $101 billion per year. The present review summarizes the different biological sources for the production of L-DOPA. The process for L-DOPA production from different biological sources has advantages over the chemical methods such as, enantiometrically pure L-DOPA, less incubation time and cost effective method. L-DOPA is found naturally in certain plant foods, particularly broad beans which found to replenish brain levels of L-DOPA even more quickly, and for longer periods, than conventional medication.

KEYWORDS

Parkinson’s Disease; L-DOPA; Biological Sources

Share and Cite:

A. Patil, S. , Apine, O. , Surwase, S. and Jadhav, J. (2013) Biological sources of L-DOPA: An alternative approach. Advances in Parkinson's Disease, 2, 81-87. doi: 10.4236/apd.2013.23016.

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