Protective Effects of Many Citrus Flavonoids on Cartilage Degradation Process - Journal of Biomaterials and Nanobiotechnology

JBNB > Vol.4 No.3, July 2013

Journal of Biomaterials and Nanobiotechnology

Volume 4, Issue 3 (July 2013)

ISSN Print: 2158-7027 ISSN Online: 2158-7043

Google-based Impact Factor: 1.69 Citations

Protective Effects of Many Citrus Flavonoids on Cartilage Degradation Process ()

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Download as PDF (Size: 422KB) PP. 279-283

DOI: 10.4236/jbnb.2013.43035 4,408 Downloads 6,021 Views Citations

Author(s)

Lucia Crascì, Annamaria Panico

Affiliation(s)

Department of Drug Sciences, Faculty of Pharmacy, University of Catania, Catania, Italy..

ABSTRACT

The objective of this study was to investigate the effects of many citrus flavanones, such as neoeriocitrin, naringin and neohesperidin, in cartilage degradation. Degenerative joint disease involved degradation of joints, including articular cartilage and subchondral bone. When bone surfaces become less well protected by cartilage, bone may be exposed and damaged. The degradation cartilage is mediated by alteration of the balance between anabolic and catabolic processes, changes in proteolytic enzyme activity, mechanical disruption of the cartilage extracellular matrix (ECM), or a combination of these processes. We examine the capability of neoeriocitrin, naringin and neohesperidin, to inhibit metalloproteinase (MMP)-13, collagenase involved in degradation of cartilage matrix components. Also, we assay the flavonoids effect on reducing of Glycosaminoglycans (GAGs) release, and restore Nitric oxide (NO) levels in explant of human articular cartilage. Our results suggest that neoeriocitrin, naringin and neohesperidin are a potential therapeutic agent to protect cartilage tissue.

KEYWORDS

Neoeriocitrin; Naringin; Neohesperidin; Metalloproteinases-13; Cartilage Degradation

Share and Cite:

L. Crascì and A. Panico, "Protective Effects of Many Citrus Flavonoids on Cartilage Degradation Process," Journal of Biomaterials and Nanobiotechnology, Vol. 4 No. 3, 2013, pp. 279-283. doi: 10.4236/jbnb.2013.43035.

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