Review point on neural stem cells and neurogenic areas of the central nervous system - Open Journal of Animal Sciences

OJAS > Vol.3 No.3, July 2013

Open Journal of Animal Sciences

Volume 3, Issue 3 (July 2013)

ISSN Print: 2161-7597 ISSN Online: 2161-7627

Google-based Impact Factor: 1.39 Citations h5-index & Ranking

Review point on neural stem cells and neurogenic areas of the central nervous system ()

HTML

Download as PDF (Size: 102KB) PP. 242-247

DOI: 10.4236/ojas.2013.33036 5,369 Downloads 8,029 Views Citations

Author(s)

Erika Toledo da Fonseca, Ana Carolina Furlanetto Mançanares, Carlos Eduardo Ambrósio, Maria Angélica Miglino

Affiliation(s)

Department of Basic Sciences of the School of Animal Science and Food Engineering, University of S?o Paulo, S?o Paulo, Brazil.
Department of Surgery, School of Veterinary Medicine and Animal Science, University of S?o Paulo, S?o Paulo, Brazil;.

ABSTRACT

The potential applications of neural stem cells (NSC) in the therapy of degenerative and traumatic diseases of the central nervous system (CNS) have aroused great scientific interest. NSCs can be recovered from specific areas of the CNS from fetuses, embryos and from adult brain as well, and under appropriate culture conditions, may be induced to differentiate into the three major neural cell types, neurons, astrocytes and oligodendrocytes. The main neurogenic areas of mammals are the subventricular zone (SVZ) and the dentate gyrus (DG) of the hippocampus, yet other areas of neurogenic potential have been identified, including frontal and parietal cortices, hippocampus and lateral wall of the lateral ventricle. Neural stem cells and differentiated neural cells are usually identified by expression of specific markers, proteins that are expressed by different cell types and/or at different stages of differentiation. The main cell markers are nestin and Sox-2 for undifferentiated NSCs, beta-III tubulin (B-III tubulin) for neurons, Galactocerebroside (GalC) for oligodendrocytes and Glial fibrillary acid protein (GFAP) for astrocytes. In general, the main neurogenic areas, the neurogenic potential of NSC and the morphological and biological characteristics of differentiated neural cells are strikingly similar among species, yet some differences have been reported. This article presents a brief review of NSCs, neurogenic areas and techniques used for their identification and characterization in humans and experimental animals.

KEYWORDS

Neurogenesis; Neural Stem Cells; Subventricular Zone; Hippocampus

Share and Cite:

Fonseca, E. , Mançanares, A. , Ambrósio, C. and Miglino, M. (2013) Review point on neural stem cells and neurogenic areas of the central nervous system. Open Journal of Animal Sciences, 3, 242-247. doi: 10.4236/ojas.2013.33036.

Cited by

[1]	Challenges and solutions for fabrication of three-dimensional cocultures of neural cell-loaded biomimetic constructs
	2021

[2]	Neural stem cells as a promising therapeutic approach in neurological diseases
	Mayyahi - Bulletin of Pharmaceutical Sciences. Assiut, 2021

[3]	Reconstruction of developmental landscapes by optimal-transport analysis of single-cell gene expression sheds light on cellular reprogramming.
	2017

[4]	An investigation of the mechanisms underpinning the effect of anti-inflammatory drugs on neural stem cells
	Thesis, 2017

[5]	Reconstruction of developmental landscapes by optimal-transport analysis of single-cell gene expression sheds light on cellular reprogramming
	2017

Journals Menu

Follow SCIRP

	+1 323-425-8868
	customer@scirp.org
	+86 18163351462(WhatsApp)
	1655362766

	Paper Publishing WeChat

Journals Menu

Home

About SCIRP

Service

Policies