A study was conducted
to see the association of retinoblastoma with age, bilaterism, Tumor size, site, grades, involvement of anterior
chamber, iris, ciliary body, choroid, sclera and optic nerve, and extraocular
extension. This was a retrospective descriptive analytical study. The records
of the Institute of Ophthalmology, King Edward Medical University/Mayo
hospital, Lahore: Pakistan January 2006-Dec 2011 was analyzed. Five years
biopsies (June 2006 to June 2012) of the retinoblastoma, from the Pathology
department, was retrieved to see optic nerve involvement in all the retrieved
specimens. The mean age was 3.54 ± 1.686 years. There were 15 cases of
bilateral retinoblastoma and 37 cases with unilateral neoplasms. The age range
of bilateral tumors was 2 - 6 years while the range in unilateral tumor was 1
- 10 years male to female ratio was 1:1.5. Among 52 cases, 37 (71.2%) patients
were unilateral retinoblastoma and 15 (28.28%) patients were with bilateral
disease. On radiological examination of patients suffering from retinoblastoma
by B-Scan (Ultrasound), there were 33 (63.5%) cases with exophytic presentation
while 18 (34.6%) cases showed endophytic morphology. On clinical
examinations, 28 patients presented with proptosis of (it was the most common
presenting sign in our patients, accounting for about 53.8% of cases), 20 cases
presented with leucocoria eye with strabismus. 29/52 patients showed involvement
with optic nerve, 17 were from 1 - 3 years age and 12 were from 4 - 6 years.
Statistically there was no difference in the involvement of optic nerve, disc
involvement and extra ocular extension with the age of patients (p = 0.217).
There was also no statistical difference seen in age and gender for but a
strong association was seen with patient’s presentation, symptoms and size of the
tumors and anterior chamber, iris, ciliary body, choroid, sclera and optic
nerve, and extra ocular extension. We concluded that a positive association was seen with tumor size and tumor extension (optic
nerve, and extraocular extension). No
Association was seen with age, gender and laterality of the tumors.