Single-Carrier (SC) transmission with the same bandwidth as Multi-Carrier (MC) transmission (such as OFDM) may have far shorter symbol duration and is considered to be more robust against time selective fading. In this paper, we proposed the novel equalization and signal separation schemes in time domain for short block length transmission, i.e., Block Linear Equalization (BLE) and Block Nonlinear Equalization (BNLE) on MIMO frequency selective fading channels. The proposed BLE uses the MMSE based inverse matrix in time domain and the BNLE utilizes the QRD-M (QR Decomposition with M algorithm) with appropriate receiver complexity. We compared the computational complexity among the conventional SC-FDE (Frequency Domain Equalization) scheme and the proposed equalizers. We also used the Low-Density Parity Check (LDPC) decoder concatenated to the proposed BLE and BNLE.