American Journal of Analytical Chemistry

Volume 4, Issue 1 (January 2013)

ISSN Print: 2156-8251   ISSN Online: 2156-8278

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Isolation and Characterization of S-Enantiomer in Montelukast

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DOI: 10.4236/ajac.2013.41008    5,111 Downloads   7,763 Views  Citations


A simple and rapid Supercritical Fluid Chromatography (SFC) Method has been developed to isolate and characterize the S-Isomer of Montelukast by using normal phase Amylose based AS-H with 250 mm × 30 mm, 5 microns column using a mobile phase system containing super critical fluid carbon dioxide (CO2) and the percentage of 2-Propanol as a mobile phase (85:15) and detection at 230 nm. The isolated S-Isomer was characterized by using FT-IR, ESI-MS, HPLC and 1H NMR. The purity of isolated S-Isomer is about 98%.

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V. Maddala, K. Kakumani, K. Chimalakonda, S. Polisetty and P. Ray, "Isolation and Characterization of S-Enantiomer in Montelukast," American Journal of Analytical Chemistry, Vol. 4 No. 1, 2013, pp. 56-61. doi: 10.4236/ajac.2013.41008.

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