Engineering

Volume 4, Issue 10 (October 2012)

ISSN Print: 1947-3931   ISSN Online: 1947-394X

Google-based Impact Factor: 0.66  Citations  

Conjugation of the Recombinant Third Domain of Human Alpha-fetoprotein with Doxorubicin Using Poly(amidoamine) Dendrimers and Study of Its Cytotoxic Activity

HTML  Download Download as PDF (Size: 195KB)  PP. 80-83  
DOI: 10.4236/eng.2012.410B021    3,167 Downloads   4,507 Views  Citations

ABSTRACT

The recombinant third domain of alpha-fetoprotein (AFP3D) is one of the promising vectors for targeted delivery of anticancer drugs to tumor cells. AFP3D-based conjugates with various anti-tumor agents have shown specific anti-tumor activity. The content of anti-tumor drugs in the preparation could be increased by including dendrimers - highly branched nanoparticles - into a targeted delivery system. In this study, we synthesized the AFP3D conjugate with doxorubicin-loaded poly(amidoamine) (PAMAM) dendrimer nanoparticles and investigated its cytotoxic activity. 

Share and Cite:

S. Kisil, V. Chernikov, M. Danilevskiy, L. Savvateeva and N. Gorokhovets, "Conjugation of the Recombinant Third Domain of Human Alpha-fetoprotein with Doxorubicin Using Poly(amidoamine) Dendrimers and Study of Its Cytotoxic Activity," Engineering, Vol. 4 No. 10B, 2012, pp. 80-83. doi: 10.4236/eng.2012.410B021.

Cited by

[1] Nanobiomaterials for Drug Delivery
2018
[2] Recombinant human alpha fetoprotein synergistically potentiates the anti-cancer effects of 1’-S-1’-acetoxychavicol acetate when used as a complex against human tumours harbouring AFP-receptors
2015
[3] Recombinant human alpha fetoprotein synergistically potentiates the anti-cancer effects of 1′-S-1′-acetoxychavicol acetate when used as a complex against human tumours harbouring AFP-receptors
Oncotarget, 2015
[4] Anticancer effects of 1's-1'-acetoxychavicol acetate and its potentiation when conjugated with human alpha fetoprotein against human tumours in Mice/Norhafiza Binti …
2015
[5] Recombinant human alpha fetoprotein synergistically potentiates the anti-cancer effects of 1′-S-1′-acetoxychavicol acetate when used as a complex …
Oncotarget, 2015

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.