Spatial structure of beta-amyloid Aβ1-40 in complex with a biological membrane model - Advances in Alzheimer's Disease

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AAD> Vol.1 No.3, December 2012

Advances in Alzheimer's Disease

Volume 1, Issue 3 (December 2012)

ISSN Print: 2169-2459 ISSN Online: 2169-2467

Google-based Impact Factor: 1.59 Citations

Open Access

Spatial structure of beta-amyloid Aβ_1-40 in complex with a biological membrane model

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DOI: 10.4236/aad.2012.13004 4,319 Downloads 8,176 Views Citations

Author(s)

Konstantin S. Usachev, Andrey V. Filippov, Oleg N. Antzutkin, Vladimir V. Klochkov

Affiliation(s)

Kazan Federal University, Kazan, Russia.
Lule? University of Technology, Lule?, Sweden.

ABSTRACT

The spatial structure of beta-amyloid Aβ_1-40 in complex with sodium dodecyl sulfate micelles as a model membrane system was investigated by ¹H-¹H two-dimensional NMR (TOCSY, NOESY) spectroscopy and molecular dynamic method calculations. On the basis of NOE and chemical shifts changes data, spatial structure of the complex beta-amyloid-model of the cell surface membrane was obtained.

KEYWORDS

¹H NMR; Two-Dimensional NMR (TOCSY, NOESY) Spectroscopy; Alzheimer’s Disease; Beta-Amyloid; Oligopeptides; Micelle

Cite this paper

Usachev, K., Filippov, A., Antzutkin, O. and Klochkov, V. (2012) Spatial structure of beta-amyloid Aβ_1-40 in complex with a biological membrane model. Advances in Alzheimer's Disease, 1, 22-29. doi: 10.4236/aad.2012.13004.

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