s physico-chemical parameters were optimized to improve lovastatin. Moreover, chemical mutation was systematically employed to enhance lovastatin yield on selected strains. Productivity of 3 ± 0.06 mg lovastatin/gm dfm was obtained prior to optimization. One factor a time followed by Response Surface Methodology (RSM) gave 4.2 ± 0.10 mg lovastatin/gm dfm yield in an optimized setup with pomegranate seed powder (5 gms), KH2PO4 (0.1% w/v), glucose (5% w/v), moisture (60% w/w), pH 5 in a 15 days fermentation cycle. The production was further increased to 6.5 ± 0.08 mg lovastatin/gm dfm through chemical mutation of the strain. This process is simple and reproducible for the production of lovastatin using pomegranate seed as an agro-industrial waste.


Lovastatin, Pomegranate Seeds; Solid Substrate Fermentation; Aspergillus Terreus

Cite this paper

Naik, A. and Lele, S. (2012) Solid state fermentation of pomegranate seed for lovastatin production: a bioprocessing approach. Advances in Bioscience and Biotechnology, 3, 643-647. doi: 10.4236/abb.2012.35083.

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