International Journal of Clinical Medicine

Volume 3, Issue 3 (May 2012)

ISSN Print: 2158-284X   ISSN Online: 2158-2882

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A Patient with Intravenous Immunoglobulin-Responsive Lower Motor Neuron Syndrome

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DOI: 10.4236/ijcm.2012.33038    4,027 Downloads   5,967 Views  


We report a 50-year-old woman who developed localized proximal muscle weakness, in addition to transient elevation of antibodies to GM-1 ganglioside, without multifocal conduction block. She was treated with intravenous immunoglobulin (IVIg) and steroid pulse therapy, which were effective for over 10 years. Her clinical course and laboratory tests were consistent with lower motor neuron syndrome (LMNS) with localized proximal muscle weakness. We suggest that some patients diagnosed as LMNS may remain responsive to IVIg or steroid pulse therapy for a long time.

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T. Kessoku, T. Koide, K. Akiyama, S. Irie, T. Ishihara and F. Yoshii, "A Patient with Intravenous Immunoglobulin-Responsive Lower Motor Neuron Syndrome," International Journal of Clinical Medicine, Vol. 3 No. 3, 2012, pp. 190-193. doi: 10.4236/ijcm.2012.33038.

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