Author(s)

Angelo M. Scanu, Diana M. Stafforini, Celina Edelstein

Department of Medicine, University of Chicago, Chicago, USA.
Department of Medicine, University of Chicago, Chicago, USA; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, USA.
Huntsman Cancer Institute, University of Utah, Salt Lake City, USA.

Whereas the close structural homology between human plasminogen and apolipoprotein(a) has been known for a number of years only recent studies have revealed that both proteins carry linked oxidized phospholipids that may modify the function of these proteins. Future studies should provide a better understanding of oxidized phospholipid adducts and the role played by lipoprotein-associated phospholipase A₂ for which cleavage specificity has been established when these modified lipids are in a free form.

Plasminogen; Apolipoprotein(a); Lipoprotein(a); Oxidized Phospholipids; Oxidized Phosphatidylcholines

Scanu, A. , Stafforini, D. and Edelstein, C. (2012) Oxidized phospholipids modify plasminogen and apolipoprotein(a): Implications for vascular disease. American Journal of Molecular Biology, 2, 110-112. doi: 10.4236/ajmb.2012.22012.