Author(s)

Yiming Weng, Voon J. Chong, Leah Howard, Ruijie Huang, Richard L. Gregory, Dong Xie

Department of Biomedical Engineering, Purdue School of Engineering and Technology Indiana University-Purdue University at Indianapolis, Indianapolis, USA.
Department of Oral Biology, School of Dentistry, Indiana University Indianapolis, USA.

This study reports the synthesis and evaluation of a novel furanone-containing antibacterial resin composite. Compres-sive strength (CS) and S. mutans viability were used to evaluate the mechanical strength and antibacterial activity of the composites. With 5% to 30% addition of the furanone derivative, the composite showed no change in CS but a significant antibacterial activity with a 16% - 68% reduction in the S. mutans viability. Further, the antibacterial activity of the modified composite was not affected by human saliva. The aging study implies that the modified composite may have a long-lasting antibacterial function. Within the limitations of this study, it appears that this experimental resin composite may potentially be developed into a clinically attractive dental restorative due to its high mechanical strength and antibacterial function.

Furanone Derivative; Antibacterial; Resin Composite; CS; S. mutans Viability

Y. Weng, V. J. Chong, L. Howard, R. Huang, R. L. Gregory and D. Xie, "A Novel Antibacterial Dental Resin Composite," Journal of Biomaterials and Nanobiotechnology, Vol. 3 No. 2, 2012, pp. 130-135. doi: 10.4236/jbnb.2012.32018.