Open Journal of Pathology

Volume 2, Issue 1 (January 2012)

ISSN Print: 2164-6775   ISSN Online: 2164-6783

Google-based Impact Factor: 0.56  Citations  

Gain of Chromosomes 1, 2, 7, 10, 13 and 17 in an Acquired Cystic Kidney Disease Associated Renal Cell Carcinoma

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DOI: 10.4236/ojpathology.2012.21001    4,300 Downloads   7,675 Views  

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ABSTRACT

The acquired cystic disease of the kidney-associated renal cell carcinoma (ACDK-RCC) in the current study occurred in a kidney with multiple cysts and was composed of cells with eosinophilic cytoplasm and prominent nucleoli. There were extensive calcium oxalate deposits in both non-neoplastic cysts and tumor. The tumor cells were positive for RCC Ma, CD10, and EMA, focally positive for CK7, negative for vimentin. Interphase in situ hybridizations (FISH) were performed for chromosome 1, 2, 7, 10, 13 and 17. No chromosomal abnormality was observed in the non-neoplastic cysts. Polysomies of chromosomes 1, 2, 7, 10, 13, 17 were observed in the tumor. Trisomy 13 was first reported in this type of tumor, which warranted further study.

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S. Bai, D. Cao, D. Robirds, J. Branson and Z. Bing, "Gain of Chromosomes 1, 2, 7, 10, 13 and 17 in an Acquired Cystic Kidney Disease Associated Renal Cell Carcinoma," Open Journal of Pathology, Vol. 2 No. 1, 2012, pp. 1-5. doi: 10.4236/ojpathology.2012.21001.

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