Author(s)

Matthew Igwe Nwali^1*, Joseph Agboeze¹, Vitus Okwuchukwu Obi¹, Arinze C. Ikeotuonye¹, Ikechukwu Ogwudu Ugadu¹, Emmanuel Ajuluchukwu Ugwa²

¹Department of Obstetrics and Gynecology, Federal Teaching Hospital, Abakaliki, Nigeria.
²Department of Obstetrics and Gynecology, Federal Medical Center, Birnin Kudu, Nigeria.

Background: Cervical ripening is prerequisite of successful induction of labor. Vaginal misoprostol and Foley’s catheter placement have been widely used for this purpose but the data are not always sufficient. We attempted to determine which (misoprostol versus Foley’s catheter) is more effective/safer in Nigerian setting. Methods: A randomized controlled trial was performed at Federal Teaching Hospital Abakaliki, Nigeria, involving 135 term pregnant women requiring cervical ripening and labor induction. Participants were randomly allocated to misoprostol versus catheter group. The following were recorded/measured/analyzed: Bishop’s score, age, parity, body mass index, gestational age, labor duration, indication, oxytocin use, mode of delivery, and Apgar score. Chi square test and t test were used where appropriate. Results: At 24 hours, all of misoprostol group were either in labor, had ripe cervix, or had delivered, whereas 35.4% of catheter group had still unripe cervix (x² = 29.856, P = 0.0001). Misoprostol group was less likely to require oxytocin infusion (x² = 52.600, P = 0.0001) and less likely to require cesarean delivery (cesarean: misoprostol versus catheter: 11% versus 34% (x² = 9.800, P = 0.001)). Total medical cost for misoprostol was less than that of catheter (x² = 14.703, P = 0.0001). Conclusion: 50 μg vaginal misoprostol, compared with catheter placement, was more effective, cheaper, and safe as a procedure of cervical ripening before induction of labor.

Cervical Ripening, Labor Induction, Misoprostol, Balloon Catheter

Nwali, M. , Agboeze, J. , Obi, V. , Ikeotuonye, A. , Ugadu, I. and Ugwa, E. (2021) Cervical Ripening for Induction of Labor: A Randomized Comparison between Vaginal Misoprostol versus Foley’s Catheter Placement in a Nigeria Tertiary Hospital. Open Journal of Obstetrics and Gynecology, 11, 252-262. doi: 10.4236/ojog.2021.113024.