International Journal of Organic Chemistry

Volume 10, Issue 4 (December 2020)

ISSN Print: 2161-4687   ISSN Online: 2161-4695

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Synthesis, Characterization, and Antioxidation Evaluation of Novel Spiro-5-(fluoren-9’-yl)-6-azauracil and Their N,N-Dialkyl Derivatives

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DOI: 10.4236/ijoc.2020.104011    153 Downloads   467 Views  

ABSTRACT

In search for new antioxidant agents derived from 6-azauracil, the spiro-5-(flurin-9’-yl)-6-azauracil 3 and their N,N-disubstituted-6-azauracils 4 - 17 have been synthesized using various methods and reaction conditions. Structure of the new synthesized compounds was deduced from elemental analysis and spectral measurements, for example IR, 1H/13C NMR and mass spectroscopy. The antioxidant evaluation of the new targets showed that the activity increases in the order of 8 > 10 > 6 > 7 > 9 in comparison with 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and ascorbic acid as standards.

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Sayed, H. and Bakhotmah, D. (2020) Synthesis, Characterization, and Antioxidation Evaluation of Novel Spiro-5-(fluoren-9’-yl)-6-azauracil and Their N,N-Dialkyl Derivatives. International Journal of Organic Chemistry, 10, 144-158. doi: 10.4236/ijoc.2020.104011.

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