Author(s)

Ollandzobo Ikobo Lucie Charlotte^1,2*, Ahombo Niotsebe Lydie Bénédicte¹, Mongo-Onkouo Arnaud^1,3, Ahoui Apendi Clausina Rochelvie^1,3, Itoua Ngaporo Ngala Akoa^1,3, Mimiesse Mounanou Jile Florent^1,3, Tchidjo Ngamo Lynda¹, Déby Gassaye^1,3, Mabiala Babela Jean Robert^1,2, Atipo Ibara Blaise Irénée^1,3, Ibara Jean-Rosaire^1,3

¹Faculty of Health Sciences, Marien Ngouabi University of Brazzaville, Brazzaville, Congo.
²Infants Pediatric ward, Brazzaville University Teaching Hospital, Brazzaville, Congo.
³Gastroentérology and Internal Medicine Ward, Brazzaville University Teaching Hospital, Brazzaville, Congo.

The Helicobacter pylori (Hp) infection is a public health problem, especially in developing countries. However, the responsibility of Hp for the occurrence of recurrent abdominal pain is still unclear. Objectives: To determine the prevalence of Helicobacter pylori (Hp) infection in children with recurrent abdominal pain (RAP) in Brazzaville and to establish the relationship between Hp infection and RAP. Patients and Methods: We conducted a cross-sectional case-control study, between March and September 2018, including 106 children with RAP and 218 children without RAP, aged 2 to 17 years old, received in health centres in Brazzaville. All the children were subjected to detection of Hp fecal antigen by qualitative immuno-chromatography in the faeces. Results: The prevalence of Hp infection among children with RAP in Brazzaville was 43.4%. The female sex was most represented in both populations, with a sex ratio of 0.84 in the infected population. Compared with controls, these were children with a mean age of 8.13 ± 4.57 years. Infected children with RAP were unschooled in 66.7% (n = 31) of cases (p < 0.05). Those using potty were 63% (n = 29). Handwashing before meals and after using the toilet was not done in 66.7% (n = 31) and 56.5% (n = 26) of cases, respectively. The proportions were almost similar in the control population. The epigastric site of pain was found in 51.8% of children infected with RAP, the association between Hp infection and the site of pain was statistically significant (p = 0.009). The epidemiological factors influencing Hp infestation in children were identical in both groups, those factors were: age (OR = 0.61; p < 0.04), education level (OR = 0.35; p < 0.01) of the children and guardian’s age (OR = 1.22; p < 0.03), type of toilet (OR = 2.37; p < 0.02) and hand washing (OR = 1; p < 0.01). No statistically significant association was found between Hp infection and RAP (p = 0.10). Conclusion: Hp infection is common among children with RAP in Brazzaville. It is favoured by young age and lack of hygiene. The cause and effect relationship between Hp and RAP has not been found. Nevertheless, the search for Hp fecal antigen in children with RAP should be recommended in order to improve the management of this pathology.

Helicobacter pylori, Recurrent Abdominal Pain, Fecal Antigen, Child, Brazzaville

Charlotte, O. , Bénédicte, A. , Arnaud, M. , Rochelvie, A. , Akoa, I. , Florent, M. , Lynda, T. , Gassaye, D. , Robert, M. , Irénée, A. and Jean-Rosaire, I. (2020) Role of Helicobacter pylori Infection in Recurrent Abdominal Pain of the Child in Brazzaville. Open Journal of Pediatrics, 10, 587-599. doi: 10.4236/ojped.2020.104060.