Etiology Based Sickle Cell Disease Hepatopathy - Open Journal of Gastroenterology

OJGas > Vol.10 No.7, July 2020

Open Journal of Gastroenterology

Volume 10, Issue 7 (July 2020)

ISSN Print: 2163-9450 ISSN Online: 2163-9469

Google-based Impact Factor: 0.23 Citations

Etiology Based Sickle Cell Disease Hepatopathy ()

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Download as PDF (Size: 587KB) PP. 187-201

DOI: 10.4236/ojgas.2020.107019 512 Downloads 3,223 Views Citations

Author(s)

Hassan Al-Jafar^1*, Jameela A. Alkhaldi², Salah Termos³

Affiliation(s)

¹Hematology Department, Amiri Hospital, Ministry of Health, Kuwait City, Kuwait.
²Gastroenterology Department, Amiri Hospital, Ministry of Health, Kuwait City, Kuwait.
³Hepatobiliary & Transplant Surgery, Amiri Hospital, Ministry Of Health, Kuwait City, Kuwait.

ABSTRACT

Sickle cell disease is an autosomal recessive disorder. The vas-occlusive crises lead to microinfarcts in the microvasculature in all organs, including the liver causing acute and chronic vascular complications in the form of ischemia, sequestration, and thrombosis, it also causes acute on top of chronic hepatic manifestations. Lifelong hemolytic anemia leads to precipitations of bile salts, bile pigments in intrahepatic, and extrahepatic bile ducts, which cause an important part of liver problems in sickle cell disease. Many other etiological factors could cause sickle cell disease hepatopathy. Liver problems in such patients could be fatal complications. Dealing with these complications based on the etiological factors provides a more accurate diagnosis for the overlapping liver manifestations in sickle cell disease, which means better treatment; it also simplifies this complicated medical issue. Sickle cell disease patients require periodic biochemistry and imaging studies to detect and treat hepatic complications as soon as possible.

KEYWORDS

Sickle Cell Disease, Hepatopathy, Complication

Share and Cite:

Al-Jafar, H. , Alkhaldi, J. and Termos, S. (2020) Etiology Based Sickle Cell Disease Hepatopathy. Open Journal of Gastroenterology, 10, 187-201. doi: 10.4236/ojgas.2020.107019.

Cited by

[1]	Complicaciones y comorbilidades mÃ¡ s frecuentes en la anemia drepanocÃtica
	2021

[2]	Complicaciones y comorbilidades más frecuentes en la anemia drepanocítica
	Revista Cubana de Medicina, 2021

[3]	The Prevalence and Severity of Gallstones in Sickle Cell Disease in Kuwait
	2020

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