Scientific data concerning the impact of emotional stress to human genomic instability very seldom describes in literature. For many scientists this connection is not supposed to be obvious, although oncologists and psychologists know that a prolonged state of heightened emotional tension is fraught with serious problems for the nervous-immune-endocrine system of the or-ganism. Moreover, oncologists know that cancer is often the result of resentment and loneliness. At the same time, the role of genome instability in processes of tumor induction and progression is proved very correctly. In the report will be paying attention to 3 aspects of human life in context of emotional stress expression and its connection with genomic instability: envi-ronmental pollution, genomic predisposes, ethic and social-economic problems. The report will contain data from literature and results of own research directed to the analyzing the impact of the degree of emotional stress expression on the children’s and adults’ genomic instability. Special attention will be paid to the investigation how emotional state of parents and teachers im-pact on young children’s genomic instability. Methods. For evaluation of stress expression levels we used the complex of standard psychological tests: questionnaires— for adults and 8-coloured M. Luscher’s test—for children. Estimation of genomic instability was carried out in blood cultures by test on chromosome aberration and micronuclei test with Cytochalasin B. Alteration of biochemical indices were detected by standard methods.