Author(s)

Marcio Adriano S. Chagas^1*, Anderson Dourado Galvão¹, Fabricio Tarso de Moraes¹, A. T. B. N. Ribeiro¹, Adriano Buzutti de Siqueira¹, I. C. C. de Assis Salama¹, Wagner Welber Arrais-Silva², Katia Meirelles Duarte de Sousa¹, Claudia Cristina de Sousa Pereira¹, Wagner Batista dos Santos¹

¹Federal University of Mato Grosso, Barra do Garças, Brazil.
²Federal University of Sergipe, São Cristovão, Brazil.

Studies of coordinated compounds containing ruthenium (Ru²⁺ and Ru³⁺) have shown very effective in vitro results for the treatment of cancer and neglected diseases such as leishmaniasis. In this paper, we present the synthesis of the compound [Ru(Cl)₃(H₂O)₂(gly)], which was characterized by spectroscopic (Ultraviolet-visibleand infrared) and thermal analysis (Thermogravimetry/Derived Thermogravimetry and Thermogravimetry/Differential Thermal Analysis). The analysis of the compound in the Ultraviolet-visibleregion showed a 290 nm band λ_max (ε= 1.685 × 10³ L·cm^-1·mol^-1), attributed to the ligand metal charge transfer (LMCT). The spectroscopy (IR) showed major vibrational bands at δ_a (-COO^-) 1664 cm^-1, δ_s (-COO^-) 1388 cm^-1, δ_s () 1571 cm^-1 and δ_s (CCN) 889 cm^-1. The thermal analysis by TG/DTG and TG-DTA indicated that the complex has five consecutive stages of decomposition: at 115°C (TG = 12.18%; Calculated = 11.32%) H₂O (coordinating water), exothermic peaks at 230°C, 307°C, 440°C and 463°C due to oxidative decomposition of glycine, followed by the formation of RuClO residue at 665°C (TG = 41.11%; Calculated = 40.81%). The thermal characterization suggested the stoichiometry of the complex [RuCl₃(H₂O)₂(gly)]. The antileishmanial capacity of this compound was also evaluated and the results indicated a 31% decrease in the parasitic infection of macrophages and a 1.5 to 3 fold reduction in the number of parasites per cell after treatment with 100 μg/mL of the complex. These results support the possible use of this compound as a therapeutic alternative against medical and veterinary parasites.

Ruthenium, Glycine, Spectroscopy, Infrared TG/DTG and TG/DTA, Amino Acid

Chagas, M. , Galvão, A. , de Moraes, F. , Ribeiro, A. , de Siqueira, A. , de Assis Salama, I. , Arrais-Silva, W. , de Sousa, K. , de Sousa Pereira, C. and dos Santos, W. (2017) Synthesis, Characterization and Analysis of Leishmanicide Ability of the Compound [Ru(Cl)₃(H₂O)₂(gly)]. Open Journal of Inorganic Chemistry, 7, 89-101. doi: 10.4236/ojic.2017.74006.