Author(s)

Christian A. Umaña¹, María L. Arias², Jorge A. Cabezas^1*

¹School of Chemistry, University of Costa Rica, San José, Costa Rica.
²Faculty of Microbiology, University of Costa Rica, San José, Costa Rica.

Several aromatic homopropargyl alcohols, and derivatives were prepared by one-pot reaction of 1,3-dilithiopropyne (or its equivalent) with aldehydes and ketones. The antibacterial activity, of alcohols thus prepared, against Gram (+) and Gram (-) bacteria was tested. This activity varies depending upon substitution on the homopropargyl alcohol unit. Apparently, the benzene ring and the free hydroxyl group (or its alcoxide) are needed, in the homopropargyl alcohol unit, to be biologically active.

Homopropargyl Alcohols, 1, 3-Dilithiopropyne, Antibacterial Activity

Umaña, C. , Arias, M. and Cabezas, J. (2017) Synthesis and Antibacterial Activity of Aromatic Homopropargyl Alcohols. International Journal of Organic Chemistry, 7, 295-300. doi: 10.4236/ijoc.2017.73023.