Author(s)

Alexander Emmert^1*, Angelika Oellerich¹, Laszlo Füzesi², Regina Waldmann- Beushausen¹, Friedrich A. Schöndube¹, Hanibal Bohnenberger², Bernhard C. Danner¹

¹Department of Thoracic and Cardiovascular Surgery, University Medical Center Göttingen, Göttingen, Germany.
²Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany.

Pigment epithelium-derived factor (PEDF), a potent antiangiogenesis agent, is a multifunctional protein with important roles in regulation of inflammation and angiogenesis. It has recently attracted attention for targeting tumor cells in several types of tumors. PECAM-1 is an integral membrane protein, a cell adhesion molecule with proangiogenic activity and plays an important role in the process of angiogenesis. The correlation between proangiogenic activity PECAM-1 and antiangiogenic activity PEDF in Non-Small-Cell-Lung Cancer has not been reported. The present study was designed to evaluate using immunohistochemical techniques and multivariate analysis the interplay between PECAM-1 and PEDF in NSCLC, especially in adenocarcinoma and in squamous cell carcinoma stage IA-IIIB. Analyzing the mixed study collectively (n = 69), there was no significant correlation (p = 0.553) between PECAM-1 signal and PEDF area. Only including patients with adenocarcinoma (Figure 2), we found a positive correlation between PECAM-1 signal and PEDF area (p = 0.025). In patients with squamous cell carcinoma, we did not find a significant correlation between PECAM-1 signal and PEDF area (p = 0.530). In patients with squamous cell carcinoma, PECAM-1 and PEDF show a significant different expression pattern, measured via staining intensity (p = 0.013). These results might support the hypothesis that squamous cell carcinomas heavily rely on angiogenic processes.

NSCLC, PEDF, PECAM-1, Neoangiogenesis

Emmert, A. , Oellerich, A. , Füzesi, L. , Beushausen, R. , Schöndube, F. , Bohnenberger, H. and Danner, B. (2016) Interplay between Platelet Endothelial Cell Adhesion Molecule-1 and Pigment Epithelium-Derived Factor in Non-Small-Cell-Lung Cancer. Open Journal of Thoracic Surgery, 6, 47-56. doi: 10.4236/ojts.2016.64007.