Benign Breast Tumors among Senegalese Women: Diversity and Genetic Evolution of D-Loop - Open Access Library Journal

OALibJ > Vol.2 No.8, August 2015

Benign Breast Tumors among Senegalese Women: Diversity and Genetic Evolution of D-Loop ()

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DOI: 10.4236/oalib.1101758 928 Downloads 1,544 Views Citations

Author(s)

Daniel Doupa¹, Marc Noël Badji¹, Fatimata Mbaye^1,2, Sidy Ka³, Ahmadou Dem³, Mamadou Kane², Mbacké Sembène^1,2

Affiliation(s)

¹Department of Biology Animal, Faculty of Science and Technology, University Cheikh Anta Diop, Dakar, Senegal.
²Sudanian Sahel Animal Populations Biology (BIOPASS), Research Institute for Development (IRD), Bel-Air, Senegal.
³Cancer Institut, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal.

ABSTRACT

Subsaharan Africa, as in Senegal, breast cancer is the second after that of cervical in women. However, although most of the studies on breast pathology for cancer, the overwhelming majority of breast lesions, palpable or not are benign and some of them can become cancerous. So this research is done to understand the impact of diversity and genetic evolution of the D-loop in benign breast lesions in senegalese women. The variability of the D-loop was investigated by PCR-sequencing, in twenty eight patients with benign breast tumor. The results revealed a significant presence of specific variants for breast benign tissue, as well as control tissues. The C150T mutation was associated with protection to the presence of benign breast tumors and G247A mutation implicated in an increased risk. Patients of mitochondrial haplogroup L would be significantly more susceptible to these benign breast lesions. And the study of the genetic evolution of breast benign tumors revealed that the D-Loop is not under selection. Finally, a significant correlation was associated with haplotypes C309CC and witnessed the D310, which respectively constitute increased risk groups and susceptible to the contraction of benign breast lesions. All these results allowed to have a global view on the influence of pathogenic mutations on diversity and genetic evolution of the D-Loop observed in senegalese patients with benign breast tumor.

KEYWORDS

Tumor, Benign, Breast Cancer, D-Loop, Diversity, Genetic Evolution, Senegal

Share and Cite:

Doupa, D. , Badji, M. , Mbaye, F. , Ka, S. , Dem, A. , Kane, M. and Sembène, M. (2015) Benign Breast Tumors among Senegalese Women: Diversity and Genetic Evolution of D-Loop. Open Access Library Journal, 2, 1-6. doi: 10.4236/oalib.1101758.

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