Study on landscape spatial pattern in the center of Chengdu City is based on the Landsat-8 image by using 3S technique and spatial pattern analysis software Fragstats 3.3. The results showed that there covered an area of 193.92 km² in the center of Chengdu City. 55.24% of the total area was made up of buildings, covering an area of 107.12 km², and the overall landscape of impervious ground-based. There were 22,666 patches; 29.67% of the patches were roads. The human interference of buildings, roads and green space was a maximum; fragmentation of the highest was green space. The fragmentation of overall urban landscape was high; the diversity was low; the value of Shannon’s diversity index was 0.63; the value of Shannon’s evenness index was 0.70. All kinds of landscape distribution were not balanced, and lack of connectivity. This research puts important reference for creating good urban landscape space and restoring the natural ecological environment in the western regions of China.