Author(s)

Anatoliyi N. Pyrko¹, Gennadiyi S. Lyubin², Stanislove L. Bondarev³

¹International State Ecological University Named after A. D. Sakharov, Minsk, Belarus.
²Institute of Bioorganic Chemistry NAS of Belarus, Minsk, Belarus.
³Minsk State Higher Radiotechnical College, Minsk, Belarus.

2-Acetyl-5, 5-dimethyl-2-cyclohexen-l-one reacts with decalin-1,3-dions (9a, b) and 4-hydroxy-coumarins (13a, b) following the pattern of a Michael addition with the formation of tricyclic compounds (10a, b and 14a, b). In the case of unsubstituted 2-acetyl-2-cyclohexen-l-one reaction with 4-hydroxycoumarine follows pattern of a DieIs-Alder heterodiene condensation to form tetracycle (15). Dehydration of both types of adduct gives tetracyclic compounds (11a, b and 16a, b, c). Coumarine derivatives (14a, b, 15, 16c) were tested for anticoagulative activity.

Synthesis, Decalindion and Coumarine Derivatives, Anticoagulative Activity

Pyrko, A. , Lyubin, G. and Bondarev, S. (2014) Synthesis of Tri- and Tetracycle Compounds via Reaction of 1,3-Decalinediones and 4-Hydroxycoumarines with 2-Acetyl-2-Cyclohexenes and Biological Testing. Open Access Library Journal, 1, 1-8. doi: 10.4236/oalib.1100749.