Analysis on Immune Tolerance and Resistance Mechanism of Cryptococcus albidus of AIDS Patients with Opportunistic Cryptococci Infection - Advances in Infectious Diseases

AID > Vol.5 No.3, September 2015

Analysis on Immune Tolerance and Resistance Mechanism of Cryptococcus albidus of AIDS Patients with Opportunistic Cryptococci Infection ()

HTML

Download as PDF (Size: 340KB) PP. 118-124

DOI: 10.4236/aid.2015.53014 3,064 Downloads 3,787 Views

Author(s)

Xiaobing Yang^1*, Guosheng Su^2*, Lida Mo²

Affiliation(s)

¹The Guangxi Zhuang Autonomous Region, Longtan Hospital of the People’s Republic of China, Liuzhou, China.
²The Fourth People’s Hospital Clinical Laboratory Nanning Guangxi, Guangxi Medical University Affiliated to Infectious Diseases Hospital of Nanning, Guangxi AIDS Clinical Treatment Center, Nanning, China.

ABSTRACT

Objective: To explore more about the immune tolerance and drug resistance of white Cryptococci albidus in AIDS patients with opportunistic Cryptococcus infection. Methods: To analyze drug resistance of the samples of white Cryptococcus albidus extracted from opportunistic infection AIDS patients in the certain infection area from October 2011 to December 2014. Results: After analyzing two samples of Cryptococcus albidus from 885 cases with opportunistic infection, we found that one of the samples do resist to ten common antibiotics. They were fluconazole, flu-cytosine, fluconazole, caspofungin, amphotericin B, MI miconazole, terbinafine, ketoconazole and itraconazole. The other one was sensitive to voriconazole, but resistant to the rest of the drug. Two strains of bacteria were inoculated into the animals in vivo and their DNA was extracted to carry out the genotyping analysis. The results showed that different degrees of resistance gene amplification bands were found in the 10 kinds of antibiotics. Conclusion: Although there were few opportunistic infection Cryptococcus albidus in AIDS patients, it was easy to show its resistance to drugs. Therefore, great attention should be paid to it for the medical workers.

KEYWORDS

AIDS Patients, Opportunistic Infections, Cryptococcus albidus, Analysis of Drug Resistance

Share and Cite:

Yang, X. , Su, G. and Mo, L. (2015) Analysis on Immune Tolerance and Resistance Mechanism of Cryptococcus albidus of AIDS Patients with Opportunistic Cryptococci Infection. Advances in Infectious Diseases, 5, 118-124. doi: 10.4236/aid.2015.53014.

Journals Menu

Follow SCIRP

	+1 323-425-8868
	customer@scirp.org
	+86 18163351462(WhatsApp)
	1655362766

	Paper Publishing WeChat

Journals Menu

Home

About SCIRP

Service

Policies