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α-Galactosyl Phytosphingosine 2,6’-Diamide as an Inducer of Invariant Natural Killer T Cell

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DOI: 10.4236/ojmc.2013.33008    2,912 Downloads   5,016 Views

ABSTRACT

Four a-galactosyl phytosphingosine 2,6’-diamide analogs were prepared from 2,6’-diamino a-galactosylphytosphingosine and the aromatic-bearing carboxylic acids. After purification with High Performance Liquid Chromatography, a flowcytometry for the four compounds for stimulation of human Va24+/Vb11+ NKT cell populations was carried out. Additional keto groups on the acyl chains of the 2,6’-diamide compound was associated with the enhanced stimulating effect.


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Y. Huang, W. Chen, S. Tien, H. Huang, C. Yeh, K. Lin and C. Yu, "α-Galactosyl Phytosphingosine 2,6’-Diamide as an Inducer of Invariant Natural Killer T Cell," Open Journal of Medicinal Chemistry, Vol. 3 No. 3, 2013, pp. 55-59. doi: 10.4236/ojmc.2013.33008.

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