Author(s)

Tarique D. Perera, Arkadiy Yaretskiy, Anna V. Rozenboym, Zeena Audi, Cecilia Lipira, Jean Tang, Jeremy Hill, Lakshmi Thirumangalakudi, Daniel C. Lee, Andrew J. Dwork, Jeremy D. Coplan

Department of Biological Sciences, Kingsborough Community College, Brooklyn, USA;.
Departments of Psychiatry, College of Physicians and Surgeons, Columbia University Medical Center and New York State Psychi- atric Institute, New York, USA;.
Division of Cardiothoracic Surgery, SUNY Downstate Medical Center, Brooklyn, USA;.
Nonhuman Primate Facility, Department of Psychiatry, SUNY Downstate Medical Center, Brook- lyn, USA;.

Hippocampal neurogenesis continues throughout the lifespan of adult mammals, but the rates decline dramatically with increasing age. Among the factors that have been shown to affect neurogenesis, aging has been shown to be one of its most potent regulators in mice. The mechanism for the decline in neurogenesis with age is thought to be related to age-dependent changes in local and systemic neuroendocrinology and neurochemistry, as well as internal changes to precursor cells that result in decreased reactivity to normal stimuli. Since most of the data about neurogenesis and age were established from rodent studies, we sought to study this relationship in nonhuman primates in five previously studied cohorts of bonnet monkeys (Macaca radiata). In the present study, we statistically analyze the relationship of age and hippocampal neurogenesis rates, as measured by the number of DCX expressing cells in the subgranular zone of the dentate gyrus in 71 subjects with ages ranging from 3.5 to 17 years. We observed a non-significant relationship between age and doublecortin for subjects less than nine years old (corresponding to young and full adulthood) but a linear significant decline for subjects 9 years or greater (middle age and senescence). In contrast to previous studies that show neurogenesis to decline linearly throughout the lifespan, this study shows that neurogenesis occurs steadily throughout adulthood and begins to decline in middle age in bonnet macaques.

Neurogenesis; Age; Macaca Radiate; Nonhuman Primates

T. Perera, A. Yaretskiy, A. Rozenboym, Z. Audi, C. Lipira, J. Tang, J. Hill, L. Thirumangalakudi, D. Lee, A. Dwork and J. Coplan, "Relationship between Age and Neurogenesis in Old World Monkeys," Neuroscience and Medicine, Vol. 4 No. 3, 2013, pp. 172-180. doi: 10.4236/nm.2013.43028.