This study examined the spatial distribution of malaria in Warri metropolis. To achieve this, data were generated from medical archival records from hospitals in Warri metropolis. The medical records contain recorded cases by place of diagnosis in 2011. The data were analysed by using ANOVA to ascertain the spatial differences in the spread of malaria in the metropolis. The result revealed that malaria is at its peak in June and minimal in September owing to the heavy floods in June. It was observed that there is a variation in the prevalence of malaria in the metropolis which is significantly high in area of Okumagba layout, Jakpa, Airport road, Pessu market, Warri main market, and Igbudu market. However, the prevalence of malaria in Warri is significantly different from the prevalence of malaria in Uvwie and Udu. It is anticipated that an increase in malaria is attributed to water bodies, thus, it is recommended that vulnerability mapping should be carried out to identify areas prone to malaria.