Comparison between different methods of urine collection for estimation of albumin-creatinine ratio in patients with type-2 diabetes mellitus - Advances in Biological Chemistry

ABC > Vol.3 No.4, August 2013

Comparison between different methods of urine collection for estimation of albumin-creatinine ratio in patients with type-2 diabetes mellitus ()

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DOI: 10.4236/abc.2013.34043 7,145 Downloads 12,124 Views Citations

Author(s)

Subinay Datta, Mrinal Pal

Affiliation(s)

Department of Biochemistry, Burdwan Medical College, Burdwan, India.

ABSTRACT

In patients with diabetes mellitus, urinary albumin-creatinine-ratio (ACR) predicts progressive kidney disease. In order to determine the better urine sample for detecting ACR, we estimated ACR in three modes of urine sample. Two hundred patients of uncontrolled diabetes mellitus with proteinuria irrespective of age and sex were studied for urinary ACR in all the three types of samples over a period of 2 years. The statistical analysis showed that first morning ACR (r = 0.999, p > 0.001) of the subjects was more significantly correlated with their 24 hour urine sample ACR than spot urine (r = 0.995, p < 0.001). We conclude that early morning specimens should be used instead of spot and 24 hour sample.

KEYWORDS

Microalbuminuria; Albumin-Creatinine Ratio; Diabetic Nephropathy

Share and Cite:

Datta, S. and Pal, M. (2013) Comparison between different methods of urine collection for estimation of albumin-creatinine ratio in patients with type-2 diabetes mellitus. Advances in Biological Chemistry, 3, 403-407. doi: 10.4236/abc.2013.34043.

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