This study examines long run economic cost of HIV/AIDS on agriculture. Twenty-two African Countries were identified through purposive sampling. The sampling procedure helped to identify 1420 affected households. However, 1300 observations were found suitable for the subsequent analysis. Data were subjected to descriptive statistics and Overlapping Generation (OLG) model. The causes of high prevalence rates are the issue of poverty, fertility, myth and migration among others. Factors responsible for the classification of high HIV/AIDS prevalence rates were the patterns of spread of infectious disease that are closely associated with patterns of human mobility. For lower HIV/AIDS prevalence rate factors were low values of procreation and high values placed on morals. A positive correlation between HIV prevalence and GDP per capita was found. The study found out that there is a curvilinear relationship between the course of the HIV/AIDS epidemic and agricultural/economic growth in terms of human capita development.