The activities of endothelial elastase and cathepsin G in rats at oxidative stress caused by heavy metals salts - Advances in Biological Chemistry

ABC > Vol.3 No.2, April 2013

The activities of endothelial elastase and cathepsin G in rats at oxidative stress caused by heavy metals salts ()

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DOI: 10.4236/abc.2013.32026 3,125 Downloads 5,245 Views Citations

Author(s)

Nickolaj F. Starodub, Ljubov M. Samokhina

Affiliation(s)

Institute of Therapy of the L. T. Malaya name of AMS of Ukraine, Kharkov, Ukraine.
National University of Life and Environmental Sciences of Ukraine, Kiev, Ukraine.

ABSTRACT

CoCl₂ introduction increased cathepsin G activity in the heart and liver as well as endothelial elastase (EEl) in kidney that indicated the development of destructive processes. CoCl₂ introduction decreased EEl and cathepsin G activities in blood serum and cathepsin G in lungs. HgCl₂ injection decreased EEl in blood serum, heart, liver, kidney and cathepsin G in blood serum. These decreasing of proteinases activities may be caused by cytotoxic effects of heavy metals and/or the inclusion of these proteases in the destructive processes and absence of their synthesis and/or release.

KEYWORDS

Endothelial Elastase; Cathepsin G; Cobalt Chloride; Mercury Chloride; Rats

Share and Cite:

Starodub, N. and Samokhina, L. (2013) The activities of endothelial elastase and cathepsin G in rats at oxidative stress caused by heavy metals salts. Advances in Biological Chemistry, 3, 208-214. doi: 10.4236/abc.2013.32026.

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