Author(s)

Dongping Shao, Yanbing Yang, Fei Xue, Xianjin Luo, Reyila Wubulikasimu, Yuhuan Li, Rongmei Gao, Weidong Ye

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Zhejiang Medicine Co. Ltd., Xinchang Pharmaceutical Factory, Xinchang, China.

A series of 1,2,4-triazole derivatives were synthesized, and their abilities to inhibit the in vitro replication of Coxsackie B3/B6 were evaluated. Among the 1,2,4-triazole derivatives, compound 3 g displayed potent activity, with a high antiviral potency (IC₅₀ = 1.71 μM (against CVB3), 1.43 μM (against CVB6)). The structures of all the new synthesized compounds were confirmed by ¹H-NMR spectra, mass spectra and elemental analyses.

1, 2, 4-Triazole; Anti-Enterovirus; Coxsackie B Viruses

D. Shao, Y. Yang, F. Xue, X. Luo, R. Wubulikasimu, Y. Li, R. Gao and W. Ye, "Design, Synthesis and Inhibitory Properties against Coxsackie B3/B6 of Some Novel Triazole Derivatives," International Journal of Organic Chemistry, Vol. 3 No. 1A, 2013, pp. 41-46. doi: 10.4236/ijoc.2013.31A005.