High-pressure Raman spectroscopic experiments of anglesite, PbSO₄, were carried out in a diamond anvil cell up to about 35 GPa at room temperature. Two stages of changes in the pattern of wavenumber-versus-pressure plot were observed in most of the vibrational modes. The first stage of change is the kink in the slope of wavenumber-versus-pressure plot at about 14 GPa, indicating a change in the force constant of modes. Further compression up to 21 GPa causes the splitting in the S-O stretching modes, representing the distortion of SO₄ tetrahedron. The behavior of transition observed in PbSO₄ is similar to that of BaSO₄ as well as those found in the solid solution series of BaSO₄-SrSO₄. Transitions taking place at higher pressure for anglesite is due to the relatively greater value of electronegativity for Pb²⁺, as compared with M²⁺ in other complex compounds of similar structure.