Author(s)

Tatiana Yakhno

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This article discusses the causes of formation of micron-size protein structures in liquid plasma or serum of the patients with different diseases, which are accompanied by inflammatory reac-tions. Self-organizing processes in sessile dry-ing drops of natural and model biological liq-uids are used for study of possible mechanisms of development the protein phase instability in serum. There was shown that violation of opti-mal ratio between albumin and osmotic active components could lead to loss of albumin ag-gregative stability and albumin coagulation structures formation. Possible role of these structures in pathogenesis of inflammation is discussed.

Protein Aggregation in Serum; Mechanisms of Inflammation

Yakhno, T. (2010) Protein phase instability developed in plasma of sick patients: clinical observations and model experiments. Natural Science, 2, 220-227. doi: 10.4236/ns.2010.23034.