Special Issue on The Application of Phosphorylation in Biological Chemistry

Phosphorylation is the addition of a phosphate group to a protein or other organic molecule. Phosphorylation turns many protein enzymes on and off, thereby altering their function and activity. Protein phosphorylation is one type of post-translational modification. Protein phosphorylation in particular plays a significant role in a wide range of cellular processes. Its prominent role in biochemistry is the subject of a very large body of research.

A detailed characterization of the sites of phosphorylation is very difficult, and the quantitation of protein phosphorylation by mass spectrometry requires isotopic internal standard approaches. A relative quantitation can be obtained with a variety of differential isotope labeling technologies. There are also several quantitative protein phosphorylation methods, including fluorescence immunoassays, Microscale Thermophoresis, FRET, TRF, fluorescence polarization, fluorescence-quenching, mobility shift, bead-based detection, and cell-based formats. Antibodies can be used as powerful tools to detect whether a protein is phosphorylated at a particular site. Antibodies bind to and detect phosphorylation-induced conformational changes in the protein. Such antibodies are called phospho-specific antibodies; hundreds of such antibodies are now available.They are becoming critical reagents both for basic research and for clinical diagnosis.

In this special issue, we intend to invite front-line researchers and authors to submit original research and review articles on exploring The Application of Phosphorylation in Biological Chemistry.

Authors should read over the journal’s Author’s Guidelines carefully before submission, Prospective authors should submit an electronic copy of their complete manuscript through the journal Paper Submission System.

Please kindly notice that the “Special Issue’’ under your manuscript title is supposed to be specified and the research field “Special Issue — The Application of Phosphorylation in Biological Chemistry” should be chosen during your submission.

According to the following timetable:

Special Issue Editor

Editor-in-Chief

Prof. Gary W. Black; Northumbria University, UK

For further questions or inquiries

Please contact Editorial Assistant at

abc@scirp.org