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Dr. Fang-Ping Huang

Department of Medicine

Imperial College, UK

Email: fp.huang@imperial.ac.uk


1994  Ph.D., Immunology, University of Glasgow

1990  M.U.A., Master of University Administration, University of Glasgow

1989  M.Sc., Biochemistry/Pathology, University of Glasgow

1982  M.B., Medicine, University of Shantou

Publications (selected)

  1. Mok MY, Huang FP,Ip WK, Lo Y, Wong FY, Chan EY, Lam KF, Xu D. Serum levels of IL-33 and soluble ST2 and their association with disease activity in systemic lupus erythematosus. Rheumatology2010 Mar;49(3):520-7. Epub 2009 Dec 21.
  2. Xie Y, Fan J, Chen J, Huang FP, Cao B, Tam PK, Ren Y.A novel function for dendritic cell: clearance of VEGF via VEGF receptor-1.Biochem Biophys Res Commun. 2009 Mar 6;380(2):243-8. Epub 2009 Jan 22.
  3. Yang CH, Tian L, Ling GS, Trendell-Smith NJ, Ma L, Lo CK, Stott DI, Liew FY, Huang FP. Immunological mechanisms and clinical implications of regulatory T cell deficiency in a systemic autoimmune disorder: Roles of IL-2 versus IL-15.  Eur J Immunol. 200838:1664-76.
  4. Sun Q, Kong CT, Huang FP, Chan LC.Aberrant dendritic cell differentiation initiated by the Mll-Een fusion gene does not require leukemic transformation. J Leukoc Biol. 2008 Jan;83(1):173-80.Epub 2007 Sep 25.
  5. Chen YX, Man K, Ling GS, Chen Y, Sun BS, Cheng Q, Wong OH, Lo CK, Ng IO, Chan LC, Lau GK, Lin CL, Huang F, Huang FP.A crucial role for dendritic cell (DC) IL-10 in inhibiting successful DC-based immunotherapy: superior antitumor immunity against hepatocellular carcinoma evoked by DC devoid of IL-10. J Immunol. 2007 Nov 1;179(9):6009-15.
  6. Chen Y, Chan VS, Zheng B, Chan KY, Xu X, To LY, Huang FP, Khoo US, Lin CL.A novel subset of putative stem/progenitor CD34+Oct-4+ cells is the major target for SARS coronavirus in human lung. J Exp Med. 2007 Oct 29;204(11):2529-36.Epub 2007 Oct 8.
  7. Chan KY, Ching JC, Xu MS, Cheung AN, Yip SP, Yam LY, Lai ST, Chu CM, Wong AT, Song YQ, Huang FP, Liu W, Chung PH, Leung GM, Chow EY, Chan EY, Chan JC, Ngan HY, Tam P, Chan LC, Sham P, Chan VS, Peiris M, Lin SC, Khoo US.Association of ICAM3 genetic variant with severe acute respiratory syndrome. J Infect Dis. 2007 Jul 15;196(2):271-80.Epub 2007 Jun 5.
  8. Ma L, Chan KW, Trendell-Smith NJ, Wu A, Tian L, Lam AC, Chan AK, Lo CK, Chik S, Ko KH, To CKW, Kam SK, Li XS, Yang CH, Leung SY, Ng MH, Stott DI, Liew FY, MacPherson GG, Huang F-P. Systemic Autoimmune Disease Induced by Dendritic Cells that have Captured Necrotic but not Apoptotic Cells in Susceptible Mouse Strains. Eur J Immunol 2005 35:3364-75. (In This Issue Editorial Comments).
  9. Wong OH, Huang F-P, Chiang AKS. Differential responses of cord and adult blood-derived dendritic cells to endogenous and exogenous danger signals.Immunology 2005; 155:13-20 (Front Cover Story).
  10. Huang F-P and MacPherson GG. Dendritic cells and oral transmission of prions. Adv Drug Delivery Rev 2004; 56:906-13.
  11. Macpherson G, Milling S, Yrlid U, Cousins L, Turnbull E, Huang F-P. Uptake of antigens from the intestine by dendritic cells.Ann NY Acad Sci 2004;1029:75-82.
  12. Huang_F-P, Farquhar CF, Mabbott NA, Bruce ME and MacPherson GG. Migrating intestinal dendritic cells transport PrPScfrom the gut. J Gen Virol 2002; 83:267-71.
  13. Esfandiari E, McInnes I, Lindop G, Huang F-P, Field M, and Liew FY. A proinflammatory role of IL-18 in the development of spontaneous autoimmune disease. J Immunol 2001;167(9):5338-47.
  14. Huang_F-P and MacPherson_GG. Continuing education of the immune system – dendritic cells, immune regulation and tolerance. Current Molecular Medicine 2001; 1:457-468.
  15. Huang_F-P, Platt_N, Wykes_M, Major_JR, Powell_TJ, Jenkins_CD, MacPherson_GG. A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes. J Exp Med 2000, 191:435- 443. (Front Cover Story, Editorial Comments).
  16. Huggins ML, Huang F-P, Xu D, Lindop G and Stott DI. Modulation of autoimmune disease in the MRL-lpr/lpr 1 genebmouse by IL-2 and TGF- therapy using attenuated Salmonella typhimurium as gene carrier. Lupus 1999; 8: 29-38.
  17. Huang F-P, and MacPherson GG. Dendritic cells, mucosal immunity and peripheral tolerance. Mucosal Immunology Update, 1999; 7:11-15.
  18. Xu D, Chang WL, Leung BP, Huang F-P, Wheeler R, Piedrafita D, Robinson JH and Liew FY. Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T-cells. J Exp Med 1998; 187:787-794.
  19. Huang F-P, Niedbala W, Wei X-Q, Xu D, Feng GJ, Robinson JH, Lam C, and Liew FY. Nitric oxide regulates Th1 cell development through the inhibition of IL-12 synthesis by macrophages. Eur J Immunol 1998; 28:4062-4070.
  20. Huang F-P, Xu D, Esfandiari E, Sands W, Wei X-Q and Liew FY. Mice defective in Fas are highly susceptible to Leishmania major infection despite elevated interleukin-12 synthesis, strong Th1 responses and enhanced nitric oxide production. J Immunol 1998; 160:4143-4147. (Cutting Edge).
  21. Maclean A, Wei X-Q, Huang F-P, Alalem UAH, Chan WL and Liew FY. Mice lacking inducible nitric oxide synthase are more susceptible to Herpes simplex virus infection despite enhanced Th1 cell responses. J Gen Virol 1998; 79:825-830.
  22. Huggins ML, Huang F-P, Xu D, Lindop G and Stott DI. Modulation of the autoimmune response in lupus mice by oral administration of attenuated Salmonella typhimurium expressing the IL-2 and TGF-beta genes. Ann NY Acad Sci 1997; 815:499-502.
  23. Casey JJ, Wei XQ, Orr DJ, Gracie JA, Huang F-P, Bolton EM, Liew FY and Bradley JA. Skin allograft rejection in mice lacking inducible nitric oxide synthase. Transplantation 1997; 64:589-593.
  24. McInnes IB, Mughales JAI, Field M, Leung BP, Huang F-P, Dixon R, Sturrock RD, Wilkinson PC, Liew FY. The role of interleukin-15 in T cell migration and activation in rheumatoid arthritis. Nature Medicine 1996; 2:175-182.
  25. Huang F-P, Feng GJ, Lindop GBM, Stott DI and Liew FY. The role of interleukin-12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice. J Exp Med 1996; 183:1447-1460.
  26. McInnes IB, Leung BP, Field M, Wei X-Q, Huang F-P, Sturrock RD, Kinninmonth A, Weidner J, Mumford R and Liew FY. Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients. J Exp Med 1996; 184:1519-1524.
  27. Wei XQ, Charles IG, Smith A, Ure J, Feng G-J, Huang F-P, Xu D, Muller W, Moncada S, and Liew FY. Altered immune responses in mice lacking inducible nitric oxide synthase. Nature 1995; 375:408-411.
  28. McInnes IB, Almughales J, Huang F-P, Sturrock RD, Field M, Wilkinson PC, Liew FY. A role for interleukin-15 in T cell migration and activation in rheumatoid-arthritis (RA). Arthritis Rheum 1995; 38:490.
  29. Huang F-P, Stott DI. Dual inhibitory and stimulatory activities in serum from SLE patients and lupus mice that regulate the proliferation of an IL-2-dependent T cell line. Lupus 1995; 4: 297-303.
  30. Huang F-P, Stott DI. Restoration of an early, progressive defect in responsiveness to T-cell activation in lupus mice by exogenous IL-2. Autoimmunity  1993; 15: 19-29.

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