Prof. Kota V. Ramana

Department of Biochemistry and Molecular Biology
University of Texas Medical Branch, USA



1998 Ph.D., Postgraduate Institute of Medical Education and Research, Chandigarh, India, Biochemistry
1994 M.Sc., Indian Institute of Technology, Roorkee, India, Biosciences
1989 B.Sc, Nagarjuna University, Guntur, India, Chemistry

Publications (Selected)

  1. Shoeb M and Ramana KV. Anti-Inflammatory Effects of Benfotiamine are Mediated through the Regulation of Arachidonic Acid Pathway in Macrophages. Free Rad Biol Med. 52(1):182-90. 2012
  2. Shoeb M, Srivastava SK and Ramana KV. Inhibition of Aldose Reductase Prevents Endotoxin-Induced Inflammation by Regulating Arachidonic Acid Pathway in Murine Macrophages. Free Rad Biol Med. 51(9):1686-96, 2011
  3. Yadav UCS, Shoeb M, Srivastava SK, Ramana KV. Amelioration of Experimental Autoimmune Uveoretinitis by Aldose Reductase Inhibition in Lewis Rats. Invest Ophthalmol Vis Sci. 52(11):8033-41, 2011
  4. Yadav UCS, Shoeb M, Srivastava SK and Ramana KV. Aldose reductase deficiency protects from autoimmune- and endotoxin –induced uveitis in mice. Invest Ophthalmol Vis Sci 52(11):8076-85, 2011
  5. Tammali R, Reddy ABM, Srivastava SK and Ramana KV. Aldose reductase inhibition prevents angiogenesis in vitro and in vivo. Angiogenesis. 14:209-221, 2011
  6. Tammali R, Saxena A, Srivastava SK and Ramana KV. Aldose reductase inhibition prevents hypoxia-induced increase in HIF-1a and VEGF by regulating the 26S proteasome mediated protein degradation in human colon cancer cells. J. Biol. Chem. 286(27):24089-100, 2011
  7. Ramana KV. Aldose reductase: New insights for an old enzyme. Biomol Concepts. 2:103-114, 2011
  8. Yadav UC, Kalariya NM and Ramana KV. Emerging role of antioxidants in the prevention of uveitis complications. Curr Med Chem.  18:931-942, 2011
  9. Tammali R, Srivastava SK and Ramana KV. Targeting Aldose Reductase for the Prevention of Cancer. Curr Cancer Drug Tar. 11:560-571, 2011
  10. Reddy AB, Srivastava SK, Ramana KV. Aldose reductase inhibition prevents lipopolysaccharide-induced glucose uptake and glucose transporter 3 expression in RAW264.7 macrophages. Int J Biochem Cell Biol. 42:1039-1045, 2010
  11. Yadav UC, Sriavstava SK and Ramana KV.  Inhibition of Aldose Reductase Attenuates Endotoxin Signals in Human Non-pigmented Ciliary Epithelial Cells. Exp. Eye Res. 90:555-563, 2010
  12. Yadav UC, Kalariya NM, Reddy ABM, Srivastava SK and Ramana KV. Protective role of benfotiamine, a fat soluble vitamin B1 analogue, in the lipopolysaccharide -induced cytotoxic signals in murine macrophages. Free Rad. Biol. Med.  48:1423-34, 2010
  13. Tammali R, Srivastava SK and Ramana KV. Aldose reductase regulates vascular smooth muscle cell proliferation by modulating g1/s phase transition of cell cycle. Endocrinology 151:2140-2150, 2010
  14. Ramana KV and Srivastava SK. Aldose reductase: A novel therapeutic target for inflammatory pathologies. Int J Bichem Cell Biol. 42:17-20, 2010
  15. Yadav UC, Igani HF, VanKuijk FJ, Srivastava SK and Ramana KV. Aldose Reductase Inhibition Prevents Posterior Capsular Opacification in Porcine Eye Capsular Bag Model. Invest Ophthalmol Vis Sci. 50:752-759, 2009
  16. Tammali R, Reddy ABM, Ramana KV and Srivastava SK. Aldose Reductase Deficiency in Mice Prevents Azoxymethane –Induced Colonic Preneoplastic Aberrant Crypt Foci Formation. Carcinogenesis 30:799-807, 2009
  17. Ramana, K.V., Willis, M.S., White, M.D., Horton, J.W., DiMaio, J.M., Srivastava, D., Bhatnagar, A. and Srivastava, S.K. Endotoxicn-induced cardio myopathy and septic inflammatory in mice is prevented by aldose reductase inhibiton.  Circulation 114: 1838-1846, 2006
  18. Ramana, K.V., Fadl, A.A., Reddy, A.B.M., Tammali, R., Chopra, A.K. and Srivastava, S.K. Aldose reductase mediated the lipopolysacharide-induced release of inflammatory mediators in RAW264.7 murine macrophages. J. Biol. Chem. 281(44):33019-29, 2006
  19. Tammali, R., Ramana, K.V. and Srivastava, S.K.  Aldose reductase growth factor-induced cox-2 expression and PGE2 production in human colon cancer cells.  Cancer Res. 66: 1-9, 2006
  20. Ramana, K.V., Bhatnagar, A., Awasthi, S., Yadav, U.C.S., Awasthi, Y.C. and Srivastava, S.K. Mitogenic responses of vascular smooth  muscle cells to lipid peroxidation derived aldehdye 4-hydroxy-trans-2-nonenal (HNE): Role of aldose reductase catalyzed reduction of the HNE-glutathione conjugates in regulating cell growth. J. Biol. Chem. 281: 17652-17660, 2006
  21. Ramana, K.V., Bhatnagar, A. and Srivastava, S.K. Inhibition of aldose reductase attenuates TNF-α-induced expression of adhesion molecules in endothelial cells. FASEB J.  18: 1209-1218, 2004
  22. Ramana, K.V., Friedrich, B., Srivastava, S., Bhatnagar, A. and Srivastava, S.K. Activation of NF-κB by hyperglycemia in vascular smooth muscle cells is regulated by aldose reductase. Diabetes 53: 2910-2920, 2004
  23. Ramana, K.V., Friedrich, B., Bhatnagar, A. and Srivastava, S.K. Requirement of aldose reductase for the hyperglycemic activation of protein kinase C and formation of diacylglycerol in vascular smooth muscle cells. Diabetes 54: 818-829, 2005
  24. Srivastava, S.K., Ramana, K.V., and Bhatnagar, A. Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options. Endocrine Reviews 26:380-392, 2005

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