Prof. Mei Xu

University of Kentucky, USA

Email: mxu222@uky.edu

Qualifications

2002 Ph.D., West Virginia University, physiology and pharmacology

1984 B.Sc., Shandong University, Biology

Publications (selected)

1. Lee, W. H., Kipp, Z., Bates, E., et al. (2025). Insulin Receptor Regulates Cell Growth Rate and TGFβ-Induced Transcriptional Responsiveness and Kinase Activities in Human Hepatic Stellate Cells. Journal of Biological Chemistry, 301(5 Suppl), Meeting Abstract 2056.
2. Li, H., Xu, M., Chen, D. L., et al. (2024). Pirfenidone ameliorates alcohol-induced promotion of breast cancer in mice. Frontiers in Oncology, 14, Article 1351839.
3. Bates, E., Kipp, Z., Pauss, S., et al. (2024). PamGene Nuclear Hormone Receptor Analysis Reveals Dietary Influences of the PPARgamma Coregulator Interactome and Differential Signaling Mechanisms. Journal of Biological Chemistry, 300(3 Suppl), Meeting Abstract 1520.
4. Bates, E. A., Kipp, Z. A., Lee, W. H., et al. (2024). FOXS1 is increased in liver fibrosis and regulates TGFβ responsiveness and proliferation pathways in human hepatic stellate cells. Journal of Biological Chemistry, 300(3), Article 105691.
5. Lee, W. H., Bates, E., Maharramov, A., et al. (2024). FK506-Binding Protein 51 (FKBP51), a New Regulator of Insulin Receptor Alternative Splicing and PPARa Activation That May Control Metabolic Disorder Developments. Journal of Biological Chemistry, 300(3 Suppl), Meeting Abstract 1514.
6. Bates, E. A., Kipp, Z. A., Martinez, G. J., et al. (2023). Suppressing Hepatic UGT1A1 Increases Plasma Bilirubin, Lowers Plasma Urobilin, Reorganizes Kinase Signaling Pathways and Lipid Species and Improves Fatty Liver Disease. Biomolecules, 13(2), Article 252.
7. Kipp, Z. A., Xu, M., Bates, E. A., et al. (2023). Bilirubin Levels Are Negatively Correlated with Adiposity in Obese Men and Women, and Its Catabolized Product, Urobilin, Is Positively Associated with Insulin Resistance. Antioxidants, 12(1), Article 170.
8. Wang, F., Yang, J. L., Yu, K. K., et al. (2022). Editorial expression of concern: Activation of the NF-κB pathway as a mechanism of alcohol enhanced progression and metastasis of human hepatocellular carcinoma (Expression of Concern of Vol 14, art no 10, 2015). Molecular Cancer, 21(1), Article 222.
9. Xu, M., Li, H., Chen, D. L., et al. (2023). Adolescent- and adult-initiated alcohol exposure in mice differentially promotes tumorigenesis and metastasis of breast cancer. Alcohol: Clinical and Experimental Research, 47(2), 251–262.
10. Jiang, J. Y., Turpin, C., Qiu, G. F., et al. (2022). Zinc fingers and homeoboxes 2 is required for diethylnitrosamine-induced liver tumor formation in C57BL/6 mice. Hepatology Communications, 6(12), 3550–3562.
11. Leachman, J. R., Cincinelli, C., Ahmed, N., et al. (2022). Early life stress exacerbates obesity in adult female mice via mineralocorticoid receptor-dependent increases in adipocyte triglyceride and glycerol content. Life Sciences, 304, Article 120718.
12. Xu, W. H., Wu, L. Q., Xu, M., et al. (2022). Ethanol Exposure Up-Regulates PD-L1/PD-1 Immune Checkpoint Pathway and Promotes Mammary Tumor Development. Frontiers in Oncology, 12, Article 874156.
13. Creeden, J. F., Kipp, Z. A., Xu, M., et al. (2022). Hepatic kinome atlas: An in-depth identification of kinase pathways in liver fibrosis of humans and rodents. Hepatology, 76(5), 1376–1388.
14. Wang, Y. C., Wen, W., Li, H., et al. (2022). Deficiency of mesencephalic astrocyte-derived neurotrophic factor affects neurogenesis in mouse brain. Brain Research Bulletin, 183, 49–56.
15. Hinds, T. D., Kipp, Z. A., Xu, M., et al. (2022). Adipose-Specific PPARα Knockout Mice Have Increased Lipogenesis by PASK-SREBP1 Signaling and a Polarity Shift to Inflammatory Macrophages in White Adipose Tissue. Cells, 11(1), Article 4.
16. Chen, D. L., Yan, Y., Wang, X. Y., et al. (2021). Chronic alcohol exposure promotes HCC stemness and metastasis through β-catenin/miR-22-3p/TET2 axis. Aging (Albany NY), 13(10), 14433–14455.
17. Wu, H. X., Li, H., Wen, W., et al. (2021). MANF protects pancreatic acinar cells against alcohol-induced endoplasmic reticulum stress and cellular injury. Journal of Hepato-Biliary-Pancreatic Sciences, 28(10), 883–892.
18. Xu, H., Li, H., Liu, D. X., et al. (2021). Chronic Voluntary Alcohol Drinking Causes Anxiety-like Behavior, Thiamine Deficiency, and Brain Damage of Female Crossed High Alcohol Preferring Mice. Frontiers in Pharmacology, 12, Article 614396.
19. Wang, Y. C., Wen, W., Li, H., et al. (2021). MANF is neuroprotective against ethanol-induced neurodegeneration through AISI ameliorating ER stress. Neurobiology of Disease, 148, Article 105216.
20. Wen, W., Wang, Y. C., Li, H., et al. (2020). Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Regulates Neurite Outgrowth Through the Activation of Akt/mTOR and Erk/mTOR Signaling Pathways. Frontiers in Molecular Neuroscience, 13, Article 560020.

Profile Details
https://www.ccts.uky.edu/about-ccts/staff-directory/mei-xu-phd
https://www.researchgate.net/profile/Mei-Xu-12

WOS ResearcherID: GJT-5712-2022