Prof. Bimal K. Ray

Email: rayb@missouri.edu

Qualifications

Publications (Selected)

1. Ray, Alpana & Ray, Bimal. (2019). Suppression of vascular endothelial growth factor expression in breast cancer cells by microRNA-125b-mediated attenuation of serum amyloid A activating factor-1 level. Oncoscience. 6. 337-348. 10.18632/oncoscience.483.
2. Alalem, Mohamed & Ray, Bimal. (2018). Metformin Treatment Represses Vascular Endothelial Growth Factor Gene Transcription in MCF-7 Breast Cancer Cells. Open Access Journal of Oncology and Medicine. 1. 10.32474/OAJOM.2018.01.000115.
   
3. Alalem, M., Ray, A. and Ray, B. K. (2016) Metformin induces degradation of mTOR protein in breast cancer cells.  Cancer Med. 2016 Nov;5(11):3194-3204. doi: 10.1002/cam4.896. Epub 2016 Oct 17
4. Alalem, M, Ray, A. and Ray, B. K. (2016) Metformin treatment decreases mTOR mRNA level in MCF7 breast cancer cells. Ibnosina J. Med. Biomed Sci 99-108. journals.sfu.ca/ijmbs/index.php/ijmbs/article/viewFile/620/1183
   Ray, A. and Ray, B. K. (2015) Induction of Ras by SAF-1/MAZ through a feed-forward loop promotes angiogenesis in breast cancer.  Cancer Med. 2015 Feb;4(2):224-34. doi: 10.1002/cam4.362. Epub 2014 Nov 30
5. Ray, A., Alalem, M., and Ray, B. K. (2013) Loss of epigenetic Kruppel-like factor 4-histone deacetylase –mediated transcriptional suppression is crucial in increasing vascular endothelial growth factor expression in breast cancer.  J Biol Chem. 2013 Sep 20; 288(38): 27232–27242. Published online 2013 Aug 6. doi:  10.1074/jbc.M113.481184
6. Ray, B.K., Dhar, S., Shakya, A., Ray, A. (2011) Z-DNA-forming silencer in the first exon regulates humanADAM-12 gene expression. Proc. Natl. Acad. Sci. U.S.A. 108: 103-108
7. Ray, A., Dhar, S., Ray, B. K. (2011) Control of VEGF expression in triple negative breast carcinoma cells by suppression of SAF-1 transcription factor activity. Mol. Cancer Res. 9: 1030-1041
8. Dhulipala, V.C., Maddali, K.K., Ray, B.K., Welshons, W.V., Reddy, C.S. (2011) Role of p21 and cyclin E in normal and secalonic acid D-inhibited proliferation of human embryonic palatal mesenchymal cells. Hum. Exp. Toxicol. 30:1222-1232
9. Ray, B.K., Dhar, S., Ray, A. (2010) TGF-1mediated activation of NF-B contributes to enhanced ADAM-12 expression in mammary carcinoma cells. Mol. Cancer Res. 8: 126-1-1270
10. Mukhopadhyay,S., Mukherjee, S., Ray, B.K., Ray, A., Stone, W.L., Das, S.K. (2010)Antioxidant liposomes protect against CEES-Induced Lung Injury by decreasing SAF-1/MAZ-mediated inflammation in the guinea pig lung.J. Biochem. Mol.Toxicol. 24: 187-194
11. Kumar, D., Ray, A., Ray, B.K. (2009) Transcriptional synergy mediated by SAF-1 and AP-1: critical role  of N-terminal polyalanine and two zinc finger domains of SAF-1. J. Biol. Chem. 284: 1853-1862
12. Ray, A., Dhar, S., Shakya, A., Ray, P., Okada, Y. ,Ray, B.K. (2009) SAF-3, a novel variant of the SAF-1/MAZ/Pur-1 family, is expressed during inflammation. FEBS. J. 276: 4276-4286
13. Ray, A., Ray, B.K. (2008) An inflammation-responsive transcription factor in the pathophysiology of osteoarthritis. Biorheology 45: 399-409
14. Ray, B. K.., Shakya, A., Ray, A. (2007) VEGF expression in arthritic joint is regulated by SAF-1 transcription factor. J. Immunol. , 178: 1774-1782
15. Ray, A., Shakya, A., Kumar, D., Benson, M.D., Ray, B.K. (2006) Inflammation-responsive transcription factor SAF-1 activity is linked to the development of AA amyloidosis. J. Immunol 177: 2601-2609
16. Kovacevic, A., Hammer, A., Sundl, M., Pfister, B., Hrzenjak, A., Ray, A., Ray, B.K., Sattler, W., Malle, E. (2006) Expression of serum amyloid A transcripts in human trophoblast and fetal-derived trophoblast-like choriocarcinoma cells. FEBS Lett. 580: 161-167.
17. Ray, A., Bal, B.S., Ray, B.K. (2005) Transcriptional induction of MMP-9 in the chondrocyte and synoviocyte cells is regulated via a novel mechanism: evidence for functional cooperation between SAF-1 and AP-1. J. Immunol. 175: 4039-4048
18. Ray, A., Shakya, A., Ray, B.K. (2005) Inflammation Responsive Transcription Factors SAF-1 and c-Jun/c-Fos promote canineMMP-1gene expression. Biochim. Biophys. Acta 1732: 53-61.
19. Ray, A., Shakya, A., Kumar, D., Ray, B.K. (2004) Over-expression of SAF-1 inhibits cell proliferation by the induction of cyclin-dependent protein kinase inhibitor p21 expression. J. Immunol. 172: 5006-5015
20. Ray, A., Kumar, D., Shakya, A., Brown, C.R. Cook, J.L., Ray, B.K. (2004) SAF-1 transgenic mice are prone to develop severe form of inflammation-induced arthritis. J. Immunol. 173: 4684-4691
21. Ray, A., Kumar, D., Ray, P., Ray, B.K. (2004) Transcriptional activity of SAF-1 is regulated by distinct functional modules. J. Biol. Chem. 279: 54637-54646
22. Ray, B.K., Shakya, A., Turk, J.R., Apte, S.S., Ray, A. (2004) Induction of the MMP-14 Gene in Macrophages of the Atherosclerotic Plaque: Role of SAF-1 in the Induction Process. Circ. Res. 95: 1082-1090
23. Ray, A., Ray, P., Guthrie, N., Shakya, A., Kumar, D., Ray, B.K. (2003) Protein kinase A signaling pathway regulates transcriptional activity of SAF-1 by unmasking its DNA-binding domains. J. Biol. Chem. 278: 22586-22595
24. Ray, A., Kuroki, K., Cook, J.L., Bal, B.S., Kenter, K., Aust, G., Ray, B.K. (2003) Induction of matrix metalloproteinases-1 gene expression is regulated by inflammation-responsive transcription factor SAF-1 in osteoarthritis. Arthritis Rheum 48: 134-145
25. Ray, A., Yu, G.-Y , Ray, B.K. (2002) Cytokine responsive induction of SAF-1 activity is mediated by a MAP kinase signaling pathway. Mol. Cell. Biol.22:1027-1035
26. Ray, B.K., Murphy, R., Ray, P., Ray, A. (2002) SAF-2, a splice variant of SAF-1 acts as a negative regulator of transcription. J. Biol. Chem. 277:46822-46830
27. Ray, A., Kumar D., Ray, B.K. (2002) Promoter-binding activity of inflammation responsive transcription SAF is regulated by cyclic AMP signaling pathway. DNA Cell Biol.21:31-40
28. Ray, B.K., Chen, J., Ray, A. (2001) Catalytic subunit of protein kinase A is an interacting partner of the inflammation-responsive transcription factor SAF-1. J. Immunol.167:2343-2348
29. Ray, A., Fields, A.P., Ray, B.K. (2000) Activation of transcription factor, SAF, involves its phosphorylation by protein kinase C. J. Biol. Chem., 275: 39727-39733
30. Ray, B.K., Chatterjee, S., Ray, A. (1999) Mechanism of Minimally-modified low density lipoprotein mediated induction of the serum amyloid A gene in monocyte-macrophage cells. DNA Cell Biol 18: 65-73
31. Ray, B.K., Schatten, H., Ray, A. (1999) Induction of Sp1 and its functional cooperation with SAF in synoviocyte cells trigger synergistic action of IL-1 and IL-6 in serum amyloid A gene expression. J. Biol. Chem. 274: 4300-4308
32. Ray, A., Ray, B.K. (1999) Persistent expression of serum amyloid A during experimentally induced chronic inflammatory condition in rabbit involves differential activation of SAF, NF-κB and C/EBP transcription factors. J. Immunol. 163: 2143-2150
33. Ray, A., Ray, B.K. (1998) Isolation and structural analysis of cDNA of the serum amyloid A activating factor that binds to the serum amyloid A promoter. Mol. Cell. Biol. 18: 7327-7335
34. Ray, B.K., and Ray, A. (1997) Induction of serum amyloid A gene by SAF in monocyte/macrophage cells. Evidence for a functional synergy between SAF and Sp1. J. Biol. Chem. 272: 28948-28953
35. Ray, B.K., Ray, A. (1997) Involvement of SAF-like transcription factor in the activation of serum amyloid A gene in monocyte/macrophage cells by lipopolysaccharide. Biochemistry 36: 4662-4668
36. Ray, A., Ray, B.K. (1997) Serum amyloid A gene expression in liver in response to different inflammatory agents is dependent upon the nature of activated transcription factors. DNA Cell Biol. 16: 1-7
37. Ray, A., Ray, B.K. (1996) A novel cis-acting element is essential for cytokine mediated transcriptional induction of the serum amyloid A gene in nonhepatic cells. Mol. Cell. Biol. 16: 1584-1594
38. Jie, H.-B., Bailey, C.W., Ray, B.K., Estes, D.M., Kumar, N., Carson, C.A. (1996) Single copyBabesia microtihsp70. Mol. Biochem. Parasitol. 83: 241-246
39. Ray, A., Gao, X., Ray, B.K. (1995) Role of a distal enhancer containing a functional NF-κB binding site in lipopolysaccharide-induced expression of a novel α1-antitrypsin gene. J. Biol. Chem. 270, 29201-29208

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