Prof. Hee-Jeong Im Sampen

Departments of Biochemistry

Rush University Medical Center, USA

Associate Professor

Email: Hee-Jeong_Sampen@rush.edu

Qualifications

2014-Present Professor, Jesse Brown VA Hospital, USA

2012-Present Professor, Rush University Medical Center, USA

2008-2012 Associate Professor, Rush University Medical Center, USA

2003-2007 Assistant Professor, Rush University Medical Center, USA

1997-2000 Postdoctoral Research Associate, University of Minnesota, USA

1992-1996 Ph.D., University of New South Wales, Australia, Biotechnolgy

1990-1991 M.S., University of New South Wales, Australia, Microbiology

Publications (Selected)

1. Dongyao Yan, Di Chen, John R Hawse, Andre J van Wijnen, Hee-Jeong Im 2013 Bovine lactoferricin induces TIMP-3 via the ERK1/2-Sp1 axis in human articular chondrocytes. GENE 517(1):12-8. doi: 10.1016/j.gene.2013.01.001. PMC3463726
2. Shibing Yu, Rohit Sharma, Daibang Nie, Hongli Jiao, Hee-Jeong Im, Yumei Lai, Zhongfong Zhao, Ke Zhu, Jie Fan, Di Chen, Qingde Wang, Guozhi Xiao. 2013. ADAR1 ablation decreases bone mass by impairing osteoblast function in mice GENE 513(1):101-110. doi:pii: S0378-1119(12)01352-2. 10.1016/j.gene.2012.10.068. PMC3514579
3. Meina Wang, Erik R. Sampson, Hongting Jin, Jia Li, Hee-Jeong Im, Di Chen MMP13 is a Critical Target Gene during the Progression of Osteoarthritis. Arthritis Res Therapy 2013; 15(1):R5 PMC3672752
4. Jaesung Kim, Michael B Ellman, Dongyao Yan, Howard S An, Xin Li, Di Chen, Gabriella Cs-Szabo, David W Hoskin, DD Buechter, Andre J van Wijnen, Hee-Jeong Im. Lactoferricin antagonizes IL-1- and LPS-mediated inflammatory and catabolic effects in the intervetebral discs. J Cell Physiology 2013 228(9):1884-96 PMC3703102
5. Jianying Zhang, Kellie K. Middleton, Freddie H. Fu, Hee-Jeong Im, James H-C. Wang 2013 The Anti-inflammatory Effects of PRP on Injured Tendons. PLOS ONE 2013 8(6):e67303
6. Jie Shen, Jia Li, Baoli Wang, Hongting Jin, Meina Wang, Yejia Zhang, Yunzhi Yang, Hee-Jeong Im, Regis J. O’Keefe, Di Chen 2013 Deletion of the Type II TGF-β Receptor Gene in Articular Chondrocytes Leads to Progressive OA-like Phenotype in Mice. Arthritis Rheum 2013, 65(12): 3107-3119 DOI 10.1002/art.38122 PMC3928444
7. Shibing Yu, Ke Zhu, Yumei Lai, Zhongfang Zhao, Jie Fan, Hee-Jeong Im, Di Chen, Guozhi Xiao. 2013. ATF4 Promotes β-Catenin Expression and Osteoblastic Differentiation of Bone Marrow Mesenchymal Stem Cells International Journal of Biological Sciences 9(3):256-266 PMC3596711
8. Ke Zhu, Hongli Jiao, Shuai Li, Huiling Cao, Deborah L. Galson, Zhongfang Zhao, Xi Zhao, Yumei Lai, Jie Fan, Hee-Jeong Im, Di Chen, Guozhi Xiao. 2013. ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment J Bone Miner Res 2013 28(9):1879-84
9. Xin Li, Jeffrey S Kroin, Gary Gibson, Di Chen, Jaesung Kim, Sana Fayyaz, Ranjan KC, Andre van Wijnen, Su-Gwan Kim, Hee-Jeong Im. 2013 Altered spinal microRNA-146a and the microRNA-183 cluster contribute to osteoarthritic pain in knee joints. J Bone Miner Res 2013 28(12):2512-22
10. Huiling Cao, Ke Zhu, Lugui Qiu, Shuai Li, Hanjie Niu, Mu Hao, Shengyong Yang, Zhongfang Zhao, Yumei Lai, Judith L. Anderson, Jie Fan, Hee-Jeong Im, Di Chen, G. David Roodman, Guozhi Xiao. Critical Role of AKT Protein in Myeloma-induced Osteoclast Formation and Osteolysis. J Biol Chem. 2013 18; 288(42): 30399–30410. PMC3798504
11. Dongyao Yan, Di Chen, Guozhi Xiao, Hee-Jeong Im. Bovine lactoferricin-induced anti-inflammation is, in part, via upregulation of IL-11 by a secondary activation of Stat3 in human articular cartilage. J Biol Chem 2013 288(44):31655-69 PMC3814761
12. Michael B Ellman, Dongyao Yan, K Ahmadinia Di Chen Howard S An, Hee-Jeong Im Fibroblast growth factor control of cartilage homeostasis. J Cell Biochem 2013 114(4):735-742 doi: 10.1002/jcb.24418. PMC3690116
13. Andrew Lee, Michael B Ellman, Dongyao Yan, Jeffrey S Kroin, Brian Cole, Andre J van Wijnen, Hee-Jeong Im. A current review of molecular mechanisms regarding osteoarthritis and pain GENE 2013 527(2):440-447. doi: 10.1016/j.gene.2013.05.069 PMC3745800
14. Kasra Ahmadinia, Dongyao Yan, Michael B Ellman, Hee-Jeong Im 2013 The Anti-catabolic role of bovine lactoferricin in cartilage. Biomolecular Concepts 2013; 4(5): 495–500
15. Andre J. van Wijnen, Jeroen van de Peppel, Johannes P. van Leeuwen, Jane B. Lian, Gary S. Stein, Jennifer J. Westendorf, Merry-Jo Oursler, Hee-Jeong Im, Hanna Taipaleenmaki, Eric Hesse, Scott Riester, Sanjeev Kakar 2013. MicroRNA Functions in Osteogenesis and Dysfunctions in Osteoporosis ICMJE: Current Osteoporosis Reports 2013 11(2):72-82 PMC3678273
16. Jae-Sung Kim, Mi-Ra Park, Sook -Young Lee, Do Kyoung Kim, Sung‑Min Moon, Chun Sung Kim, Seung Sik Cho, Goo Yoon, Hee -Jeong Im, Jae Seek You, Ji-Su Oh, Su-Gwan Kim. Licochalcone A induces apoptosis in KB human oral cancer cells via a caspase-dependent FasL signaling pathway. Oncology Reports 2014, 31, 755-762
17. Marge J Piel, Jeffrey S Kroin, Andre J van Wijnen, Ranjan Kc, Hee-Jeong Im Pain assessment in animal models of osteoarthritis. GENE 2014 537(2):184-188
18. Amel Dudakovic, Emily Camilleri, Scott M. Riester, Eric A. Lewallen, Sergii Kvasha, Xiaoyue Chen, Darcie J. Radel, Jarett M. Anderson, Asha Nair, Jared Evans, Aaron Krych, Jay Smith, David R. Deyle, Janet L. Stein, Gary S. Stein, Hee-Jeong Im, Simon M. Cool, Jennifer J. Westendorf, Sanjeev Kakar, Allan B. Dietz, Andre J. van Wijnen. High-resolution molecular validation of self-renewal and spontaneous differentiation in adipose-tissue derived human mesenchymal stem cells cultured in human platelet lysate. J Cellular Biochem 2014; 115(10):1816
19. Meina Wang, Shan Li, Wanqing Xie, Jie Shen, Hee-Jeong Im, Jonathan D Holz, Meiqing Wang, Thomas GH Diekwish, Di Chen. Activation of -Catenin signaling leads to temporomandibular joint defects. Eur Cell Mater 2014 (IF: 4.887) 28:223
20. Dudakovic A, Camilleri E, Riester SM, Lewallen EA, Kvasha S, Chen X, Radel DJ, Anderson JM, Nair AA, Evans JM, Krych AJ, Smith J, Deyle DR, Stein JL, Stein GS, Hee-Jeong Im, Cool SM, Westendorf JJ, Kakar S, Dietz AB, van Wijnen AJ. High-resolution molecular validation of self-renewal and spontaneous differentiation in clinical-grade adipose-tissue derived human mesenchymal stem cells. J Cell Biochem. 2014;115(10):1816-28. doi: 10.1002/jcb.24852.
21. Kim JS, Park MR, Lee SY, Kim Do K, Moon SM, Kim CS, Cho SS, Yoon G, Hee-Jeong Im, You JS, Oh JS, Kim SG. Licochalcone A induces apoptosis in KB human oral cancer cells via a caspase-dependent FasL signaling pathway. Oncol Rep 2014 31(2):755
22. Lu Y, Ding M, Wang Q, Li J, Li X, Gu J, Hee-Jeong Im, Lei G, Zheng Q. Col10a1-Runx2 transgenic mice with delayed chondrocyte maturation are less susceptible to developing osteoarthritis. Am J Transl Res 2014 Nov 22;6(6):736-45.
23. Mi-Ra Parka, Su-Gwan Kim, In-A Choa, Dahye Oha, Sook-Young Lee, Sung-Min Moon, Seung Sik Cho, Goo Yoon, Chun Sung Kim, Ji-Su Oh, Jae-Seek You, Do Kyung Kim, Yo-Seo Seo, Hee-Jeong Im, Jae-Sung Kim. Licochalcone-A Induces Intrinsic and Extrinsic Apoptosis via ERK1/2 and p38 Phosphorylation-mediated TRAIL Expression in Head and Neck Squamous Carcinoma FaDu Cells Food and chemical toxicology 2015; 77C:34
24. Su-Xi Gu, Xin Li, John L Hamilton, Ana Chee, Ranjan Kc, Di Chen, Howard S An, Jae-Sung Kim, Chun-do Oh, Yuan-Zheng Ma, Andre J van Wijnen, Hee-Jeong Im. MicroRNA-146a reduces IL-1 dependent inflammatory responses in the intervertebral disc. GENE 2015 555(2):80
25. Jae-Sung Kim, Dahye Oh, Min-Ji Yim, Jin-Ju Park, Kyung-Rok Kang, Sung-Min Moon, Ji-Su Oh, Jae-Seek You, Chun Sung Kim, Do Kyung Kim, Sook-Young Lee, Gyeong-Je Lee, Hee-Jeong Im, Su-Gwan Kim. Berberine induces FasL-related apoptosis through p38 activation in human KB oral cancer cells. Oncology Reports, 2015, 33:1775
26. Piel MJ, Kroin JS, Hee-Jeong Im. Assessment of knee joint pain in experimental rodent models of osteoarthritis. Methods Mol Biol 2015; 1226:175-81.
27. Ranjan Kc, Xin Li, Robin M Voigt, Michael B Ellman, Keith C Summa, Martha Hotz Vitaterna, Ali Keshavarizian, Fred W Turek, Qing-Jun Meng, Gary S. Stein, Andre J. van Wijnen, Di Chen, Christopher B Forsyth and Hee-Jeong Im. Environmental disruption of circadian rhythm predisposes mice to osteoarthritis-like changes in knee joint. J Cell Phy 2015 [in press]
28. This publication has been recognized as a Key Scientific Article contributing to excellence in biomedical research and highlighted in the Global Medical Discovery Series. (https://globalmedical discovery.com).
29. Ranjan Kc, Robin Voigt, Michael B Ellman, Xin Li, Keith C. Summa, Christopher B Forsyth, Ali Keshavarzian, Fred W. Turek, Jae-Sung Kim and Hee-Jeong Im Chronic alcohol consumption induces osteoarthritis-like pathological changes in an experimental mouse model Arthritis Rheum 2015 [in press]
30. Jeffrey S. Kroin, Asokumar Buvanendran, Moric M, Hee-Jeong Im, Kenneth J. Tuman, Sasha H. Shafikhani. Short term Glycemic Control is Effective in Reducing Surgical Site Infection in Diabetic Rats. J Anesthesia and Analgesia 2015 [in press]
31. Jaesung Kim, Mir H Ali, Frank Wydra, Xin Li, Howard S An, Gabriella Cs-Szabo, John M Cavanaugh, Hee-Jeong Im. Characterization of degenerative human facet joints and capsular tissues Osteoarthritis Cartilage 2015 [in press]
32. Jae-Sung Kim, Kasra Ahmadinia, Xin Li, John L Hamilton, Chris A. Haralampus, Su-Gwan Kim and Hee-Jeong Im Development of experimental animal model with lower back pain by percutaneous injury-induced lumbar facet joint osteoarthritis. J Cell Phy 2015 [in press]
33. Lee GJ, Cho IA, Kang KR, Oh D, Kim DK, Sohn HM, You JW, Oh JS, Seo YS, Yu SJ, You JS, Kim CS, Kim SG, Kim JS, Hee-Jeong Im. Biological effects of the herbal plant-derived phytoestrogen bavachin in primary rat chondrocytes. Bulletins of the Pharmaceutical Society of Japan 2015 [in press]
34. Chuanyue Wu, Hongli Jiao, Yumei Lai, Wei Zheng, Ka Chen, Hong Qu, Weimin Deng, Pingping Song, Ke Zhu, Huiling Cao, Deborah Galson, Jie Fan, Hee-Jeong Im, Yujie Liu, Ju Chen, Di Chen, Guozhi Xiao. Kindlin-2 controls TGF-β signaling and Sox9 expression to regulate chondrogenesis. Nature Communication 2015 [in press]