Prof. Sivagnanam Thamilselvan

Department of Urology

Henry Ford Health System, USA

Senior Scientist

College of Integrated Science and Technology

James Madison University, USA

Associate Professor

Email: sthamil1@hfhs.org

Qualifications

1993 Ph.D., University of Madras, India, Medical Biochemistry

1988 M.Phil., University of Madras, India, Medical Biochemistry

1987 M.Sc., University of Madras, India, Medical Biochemistry

1983 B.Sc., Loyola College, India, Zoology

Publications

1. Thamilselvan, V, Menon, M, Thamilselvan, S. (2011) Selective Rac1 inhibition protects renal tubular epithelia cells from oxalate-induced NADPH oxidase-mediated oxidative cell injury Urol Res, Aug 4. DOI: 10.1007/s00240-011-0405-7
2. Thamilselvan V, Menon M and Thamilselvan S (2011). Anticancer efficacy of deguelin in human prostate cancer cells targeting glycogen sunthase kinase-3 b/b-catenin pathway Int J Cancer. Jan 20. doi: 10.1002/ijc.25949.
3. Siva S, Barrack ER, Reddy GP, Thamilselvan V, Thamilselvan S, Menon M, Bhandari M (2009) A critical analysis of the role of gut Oxalobacter formigenes in oxalate stone diseasae BJU Int. 103(1): 18-21.
4. Thamilselvan V, Menon M and Thamilselvan S (2009). Oxalate-induced activation of PKC-alpha and -delta regulates NADPH oxidase-mediated oxidative injury in renal tubular epithelial cells. Am J Physiol Renal Physiol. 297(5):F1399-410.
5. Thamilselvan S and Menon M (2005). Vitamin-E therapy prevents hyperoxaluria induced calcium oxalate crystal deposition in the kidney by improving renal tissue antioxidant status. BJU-International. 96: 117-126.
6. Rashed T, Menon M and Thamilselvan S (2004). Molecular mechanism of oxalate induced free radical production and glutathione redox imbalance in renal epithelial cells: effects of antioxidants. Am. J Nephrol. 24(5) 557-68.
7. Thamilselvan S, Khan SR, and Menon M. (2003). Oxalate and calcium oxalate mediated free radical toxicity in renal epithelial cells: effect of antioxidants. Urol Res. 31(1): 3-9.
8. Khan SR and Thamilselvan S (2000). Review- Nephrolithiasis: a consequence of renal epithelial cell exposure to oxalate and calcium oxalate crystals. Mol Urol. Winter; 4(4): 305-12.
9. Thamilselvan S, Byer KJ, Hackett, RL and Khan SR (2000). Free radical scavengers, catalase and superoxide dismutase, provide protection from oxalate associated injury to LLC-PK1 and MDCK cells. Journal of Urology, 164:224-229.
10. Khan SR, Maslamani F, Atmani F, Thamilselvan S, Glenton PA, Opalko C and Hammett S (2000). Membranes and their lipids as promoters of calcium oxalate crystal formation in human urine. Calcified Tissue International, 66(2): 90-6.
11. Thamilselvan S., Raymond L Hackett and Saeed R Khan, (1999). Cells of proximal and distal tubular origin respond differently to challenges of oxalate and calcium oxalate crystals. Journal of the American Society of Nephrology, 10:S452-S456.
12. Peck, AB., Thamilselvan S., Cornelius JG., Khan SR. and Sidhu H (1999). Direct correlation between hyperoxaluria/oxalate stone disease and the absence of the GI-dwelling bacterium, oxalobacter formigenes: Treatment and prevention by gut recolonization and enzyme-replacement therapy. Journal of the American Society of Nephrology, 10:S334-S340.
13. Khan SR, Byer KA, Thamilselvan S, Hackett RL, McCormack WT, Benson NA, Vaughn KL, and Erdos GN (1999). Crystal-cell interaction and apoptosis in oxalate associated injury of renal epithelial cells. Journal of the American Society of Nephrology, 10:S457-S463.
14. Thamilselvan, S and Saeed R. Khan. (1998). Oxalate and calcium oxalate crystals are injurious to renal epithelial cells: results of in vivo and in vitro studies. Journal of Nephrology, 11 S-1: 66-69.
15. Thamilselvan, S., Hackett, R.L. and Khan, S.R. (1997). Lipid Peroxidation in Ethylene Glycol Induced Hyperoxaluria and Calcium Oxalate Crystalluria. Journal of Urology, 157: 1059-1063.
16. Thamilselvan, S and Selvam R. (1997). Effect of vitamin E and mannitol on renal calcium oxalate retention in experimental nephrolithiasis. Indian J. Biochem. Biophys., 34: 319-323.
17. Thamilselvan S. and Khan SR. (2000). Free radical scavengers, catalase and superoxide dismutase, provide protection from oxalate associated injury to LLC-PK1 and MDCK cells. In: Urolithiasis 2000 (Rodgers AL, Hibbert BE, Hess B, Khan SR and Preminger GM, eds.). Proc. 9^th International Symposium on Urolithiasis, pp 229-231.
18. Cornelius JG, Allison MJ, Thamilselvan S and Peck AB. (2000). Colonization with Oxalobacter formigenes for the regulation of hyperoxaluria. In: Urolithiasis 2000 (Rodgers AL, Hibbert BE, Hess B, Khan SR and Preminger GM, Eds.). Proc. 9^thInternational Symposium on Urolithiasis, pp 185-188.