Dr. Mahzuz Karim

Norfolk and Norwich University Hospital, UK

Royal College of Physicians, UK

University of East Anglia, UK

Email: mkarim@doctors.org.uk

Qualifications

2003 Ph.D., University of Oxford, UK

1992 M.Sc., University of Cambridge School of Clinical Medicine, UK

1992 B.Sc., University of Cambridge, UK

Publications

1. Immunoregulatory T-cells can mediate specific unresponsiveness to alloantigens in vivo K.J. Wood, M. Hara, C.I. Kingsley, M. Karim, A.R. Bushell, P.J. Morris Transplanation Proceedings November 2001; 3 (7-8): 3829-3830
2. CD25⁺CD4⁺ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses C.I. Kingsley, M. Karim, A.R. Bushell, K.J. Wood Journal of Immunology February 1st 2002; 168 (3): 1080-1086
3. The role of the graft in establishing tolerance M. Karim, U. Steger, A.R. Bushell, K.J. Wood Frontiers in Bioscience May 1st 2002; 7: e129-154
4. Regulatory T cells in transplantation M. Karim, A.R. Bushell, K.J. Wood Current Opinion in Immunology October 2002; 14 (5): 584-591
5. Renal failure due to scleroderma with thrombotic microangiopathy developing in a woman treated with carboplatin for ovarian cancer M. Karim, E. Vaux, D.R. Davies, P.D. Mason Clinical Nephrology November 2002; 58 (5): 384-388
6. Transplantation tolerance K. Wood, I. Binet, M. Karim, W. Wong In: Horizons in Medicine Number 14, James Neuberger, editor. Royal College of Physicians of London, 2003, pages 275-279
7. Pre-transplant blood transfusion without additional immunotherapy generates CD25⁺CD4⁺ regulatory T cells: A potential explanation for the blood transfusion effect A. Bushell, M. Karim, C.I. Kingsley, K.J. Wood Transplantation August 15th 2003; 76 (3): 449-455
8. Rapidly progressive irreversible renal failure in patients with pancreatic insufficiency
9. P. Hill, M. Karim, D.R. Davies, I.S.D. Roberts, C.G. Winearls American Journal of Kidney Diseases October 2003; 42 (4): 842-845
10. Regulatory cells in transplantation K.J. Wood, H. Ushigome, M. Karim, A. Bushell, S. Hori, S. Sakaguchi In: Generation and Effector Functions of Regulatory Lymphocytes, Gregory Bock and Jamie Goode, editors. John Wiley & Sons, 2003, pages 177-193
11. Alloantigen-induced CD25⁺CD4⁺ regulatory T cells can develop in vivo from CD25^-CD4⁺ precursors in a thymus-independent process M. Karim, C.I. Kingsley, A.R. Bushell, B.S. Sawitzki, K.J. Wood Journal of Immunology January 15th 2004; 172 (2): 923-928
12. Proliferative glomerulonephritis associated with mantle cell lymphoma – natural history and effect of treatment in two casesM. Karim, P. Hill, G. Pillai, K. Gatter, D.R. Davies, C.G. Winearls Clinical Nephrology June 2004; 61 (6): 422-428
13. A simple method to cure established tumors by inflammatory killing of normal cells
14. G.A. Daniels, L. Sanchez-Perez, R.M. Diaz, T. Kottke, J. Thompson, M. Lai, M. Gough, M. Karim, A. Bushell, H. Chong, A. Melcher, K. Harrington, R.G. Vile Nature Biotechnology September 2004; 22 (9): 1125-32
15. CD25+CD4+ regulatory T cells generated by exposure to a model protein antigen prevent allograft rejection: antigen-specific re-activation in vivo is critical for bystander regulation M. Karim, G. Feng, K.J. Wood, A.R. Bushell Blood June 15th 2005; 105 (12): 4871-4877
16. IFN-gamma production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo B. Sawitzki, C.I. Kingsley, V. Oliveira, M. Karim, M. Herber, K.J. Wood Journal of Experimental Medicine June 20th 2005; 201 (12): 1925-1935
17. CD25+CD4+ regulatory T cells develop in mice not only during spontaneous acceptance of liver allografts but also after acute allograft rejection U. Steger, C.I. Kingsley, M. Karim, A.R. Bushell, K.J. Wood Transplantation November 15th 2006; 29 (9): 1202-1209
18. Management of acute renal failure D.V. Hamilton, M. Karim Foundation Years Journal 2007; 1 (4): 189-191
19. Exhaustive differentiation of alloreactive CD8+ T cells: critical for determination of graft acceptance or rejection U. Steger, C. Denecke, B. Sawitzki, M. Karim, N.D. Jones, K.J. Wood Transplantation May 15th 2008; 85 (9): 1339-1347
20. Pulmonary fibrosis – an uncommon manifestation of anti-myeloperoxidase positive systemic vasculitis? A. Bhanji, M. KarimNDT Plus August 2010; 3 (4): 351-353