Dr. Feng Cheng

Department of Pharmaceutical Sciences, College of Pharmacy
University of South Florida, USA

Assistant professor



2010  Ph.D., University of Virginia, Biophysics

2003  Ph.D., Chinese Academy of Science, Medicinal Chemistry

1998  B.Sc., Nanjing University, Chemistry


  1. Spatiotemporal transcriptome of the human brain. Hyo Jung Kang*, Yuka Imamura Kawasawa*, Feng Cheng*, Ying Zhu*, Xuming Xu, Mingfeng Li*, André M. M. Sousa, Mihovil Pletikos, Kyle A. Meyer, Goran Sedmak, Tobias Guennel, Yurae Shin, Matthew B. Johnson, Željka Krsnik, Simone Mayer, Sofia Fertuzinhos, Sheila Umlauf, Steven N. Lisgo, Alexander Vortmeyer, Daniel R. Weinberger, Shrikant Mane, Thomas M. Hyde, Anita Huttner, Mark Reimers, Joel E. Kleinman and Nenad Šestan. Nature 2011 478, 483–489 * Equal Contribution.
  2. In vitro transcriptomic prediction of hepatotoxicity for large drug screening. Feng Cheng, Dan Theodorescu Ira G. Schulman, and Jae K. Lee. Journal of Theoretical Biology 2011, 290C, 27-36.
  3. Multi-gene molecular signatures for predicting the risk of atherosclerosis. Feng Cheng, Ellen C. Keeley, Klaus Ley, and Jae K. Lee. BMC Medical Genomics 2012 5:2.
  4. Multivariate molecular expression-based predictions of clinical outcome. Feng Cheng, Sang-Hoon Cho, and Jae K. Lee. “Statistical Methods in Molecular Biology”. Human Press, 2010.
  5. Interaction Models of a Series of Oxadiazole-Substituted alpha-Isopropoxy Phenylpropanoic Acids Against PPAR alpha and PPAR gamma. Feng Cheng, Jianhua Shen, Xiaoying Xu, Xiaomin Luo, Kaixian Chen, Xu Shen and Hualiang Jiang. Protein and Peptide Letters 2009, 16, 150-162.
  6. Molecular Docking Studies on the Interactions between the Thioesterase Domain of Human Fatty Acid Synthase and Its Ligands. Feng Cheng, Qinghua Wang, Florante A. Quiocho and Jianpeng Ma. PROTEINS: Structure, Function, and Bioinformatics 2008, 1228-1234.
  7. A Solid State 13C NMR, Crystallographic and Quantum Chemical Investigation of Chemical Shifts and Hydrogen Bonding in Histidine Dipeptides. Feng Cheng, Haihong Sun Yong Zhang, Dushyant Mukkamala and Eric Oldfield. J. Am. Chem. Soc. 2005, 127(36): 12544-12554.
  8. Inhibition of Isoprene Biosynthesis Pathway Enzymes by Phosphonates, Bisphosphonates, and Diphosphates. Feng Cheng and Eric Oldfield. J. Med. Chem. 2004, 47: 5149-5158.
  9. Quantum Chemistry Study on the Interaction of the Exogenous Ligands and the Catalytic Zinc Ion in Matrix Metalloproteinases. Feng Cheng, Xiaomin Luo, Jianhua Shen, Xin Li, Jiande Gu, Weiliang Zhu, Ruihao Zhang, Jingkang Shen, Irit Sagi, Ruyun Ji, Kaixian Chen and Hualiang Jiang. J. Phys. Chem. B, 2002, 106: 4552-4559.
  10. Steered Molecular Dynamics Simulations on the Tail Helix Latch Hypothesis in the Gelsolin Activation Process. Feng Cheng, Jianhua Shen, Xiaomin Luo, Hualiang Jiang and Kaixian Chen. Biophys. J. 2002, 83: 753-762.
  11. Molecular Docking and 3D-QSAR Studies on the Possible Antimalarial Mechanism of Artemisinin Analogues. Feng Cheng, Jianhua Shen, Xiaomin Luo, Weiliang Zhu, Jiande Gu, Ruyun Ji, Hualiang Jiang and Kaixian Chen. Bioorg. & Med. Chem. 2002, 10: 2883-2891.
  12. The progress in the design of Matrix metalloproteinase. Feng Cheng, Hong Liu, Hualiang Jiang, Kaixian Chen and Ruyun Ji. Progress in Chemistry (Chinese), 2001, 13(4): 283-293.
  13. The research progress of PPAR agonists. Feng Cheng, Jianhua Shen, Xiaomin Luo, Jingkang Shen, Hualiang Jiang and Kaixian Chen. Chin. Med. Chem.(Chinese) 2003, 13: 110-120.
  14. Crystal Structure of Unliganded Influenza B Virus Hemagglutinin. Qinghua Wang, Feng Cheng, Mingyang Lu, Xia Tian, and Jianpeng Ma. Journal of Virology 2008, 82: 3011–3020.
  15. Agonist-PPAR Interactions: A Molecular Modeling Study with Docking Approach. Xiaoying Xu, Feng Cheng, Jianhua Shen, Xiaomin Luo, Lili Chen, Liduo Yue, Yi Du, Fei Ye, Shanhao Jiang, Dayuan Zhu, Hualiang Jiang and Kaixian Chen. Int. J. Quantum Chem. 2003, 93: 405-410.
  16. Binding Mechanism of H5N1 Influenza Virus Neuraminidase with Ligands and its Implication for Drug Design. K. Gong, L. Li, J.-F. Wang, F. Cheng, D.-Q. Wei and K.-C. Chou. Medicinal Chemistry 2009, 5, 242-249
  17. Concordant gene expression signatures predict clinical outcomes of cancer patients undergoing chemotherapy. Paul D. Williams, Sooyoung Cheon, Dmytro M. Havaleshko, Hyeon Jeong, Feng Cheng, Dan Theodorescu and Jae K. Lee. Cancer Research 2009, 69 (21), 8302-8309.
  18. Virtual Screening on Natural Products for Discovering Active Compounds and Target Information. Jianhua Shen, Xiaoying Xu, Feng Cheng, Hong Liu, Xiaomin Luo, Jingkang Shen, Kaixian Chen, Weimin Zhao, Xu Shen and Hualiang Jiang. Curr. Med. Chem. 2003, 10, 1241-1253.
  19. Structure-Based 3-D-QSAR Analysis of Marine Indole Alkaloids. Biao Jiang, Wen-Nan Xiong, Cai-Guang Yang, Hua-Liang Jiang, Feng Cheng, Kai-Xian Chen. Bioorg. Med. Chem. 2002, Aug;10(8):2775-8.
  20. Binding analyses between Human PPARgamma-LBD and ligands. Changying Yu, Lili Chen, Haibing Luo, Jing Chen, Feng Cheng, Chunshan Gui, Ruihao Zhang, Jianhua Shen, Kaixian Chen, Hualiang Jiang and Xu Shen. Eur J Biochem, 2004, 271: 386-397.
  21. Structure-Based Discovery of Potassium Channel Blockers from Natural Products: Virtual Screening and Electrophysiological Assay Testing. Hong Liu, Yang Li, Mingke Song, Xiaojian Tan, Feng Cheng, Suxin Zheng, Jianhua Shen, Xiaomin Luo, Ruyun Ji, Jianmin Yue, Guoyuan Hu, Hualiang Jiang, and Kaixian Chen. Chemistry & Biology, 2003, 10,1103-1113.
  22. Differentiation of Cation-pi Bonding from Cation-pi Interactions: A Quantum Chemistry Study Using Density-Functional Theory and Morokuma Decomposition Methods. Weiliang Zhu, Xiaojian Tan, Jianhua Shen, Xiaomin Luo, Feng Cheng, Puah Chum Mok, Ruyun Ji, Kaixian Chen, Hualiang Jiang. J. Phys. Chem. A, 2003, 13: 2296-2303.
  23. Steered Molecular Dynamics Simulation on the Binding of NNRTI to HIV-1 RT.
  24. Lingling Shen, Jianhua Shen, Xiaomin Luo, Feng Cheng, Yechun Xu, Kaixian Chen, Edward Arnold, Jianping Ding, and Hualiang Jiang. Biophysical Journal, 2003, 84:3547-3563.
  25. Structure Feature of AChE Inhibitor Huperzine B in Nature and in the Binding Site of AChE: Density Functional Theory Study Combined with IR Determination. Xiaomin Luo, Feng Cheng, Xiaojian Tan, Dayuan Zhu, Kaixian Chen, Hualiang Jiang et al. J. Theo. Comput. Chem. 2002, 1: 81-92.
  26. Structural Characterization of the Catalytic Active Site in the Latent and Active Natural Gelatinase B from Human Neutrophils. Oded Kleifeld, Philippe E. Van den Steen, Anatoly Frenkeli, Feng Cheng, Hualiang Jiang, Ghislain Opdenakker, and Irit Sagi. J. Biol. Chem. 2000, 275: 34335-34343.

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Last Updated: August 2, 2012.

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