Biography

Dr. Chengxiang Wu

Tulane National Primate Research Center, USA


Email: chengxiangwu@itbiollc.com


Qualifications

2013 Ph.D., Microbiology, University of Hawai’i at Mānoa, USA


Publications (Selected)

  1. Wu C, Johnson N, Yu S, Lo A, Sahu G, Marx P, Von Laer D, Skowron G, Geleziunas R, Shaw G, Kaur A, Junghans R, and Braun S. Adoptive T Cell Immunotherapy using CMV-Specific T Cells Genetically Modified with αHIV-CAR Vectors. Journal of Experimental Medicine. (submitted)
  2. Giorgio Zenere, Cecily Midkiff, Nathan M. Johnson, Chengxiang Wu, William C. Wimley, Amitinder Kaur, and Stephen E. Braun. The Fast and The Curious: CAR motifs and hinge length affect surface expression of CAR. Human gene therapy. (in revision)
  3. Eldesouki RE, Wu C, Saleh FM, Mohamed EAM, Younes S, Hassan NELS, Brown TC, Alt EU, Robinson JE, Mohamed FB, Braun SE. Identification and targeting of Thomsen-Friedenreich and IL1RAP antigens on Chronic Myeloid Leukemia stem cells using bi-specific antibodies. Onco Targets Ther. 2021; 14: 609–621.
  4. Chandra PK, Gerlach SL, Wu C, Khurana N, Swientoniewski LT, Abdel-Mageed AB, Li J, Braun SE, Mondal D. Mesenchymal stem cells are attracted to latent HIV-1-infected cells and enable virus reactivation via a non-canonical PI3K-NFκB signaling pathway. Sci Rep. 2018 Oct 2;8(1):14702.
  5. Wu C, Yu S, Sahu G, Marx P, Skowron G, Junghans R, Kaur A, Braun S. Stimulation, transduction, and expansion of CMV-specific T cells for adoptive immunotherapy in NHP. Journal of Medical Primatology (2017), 46, Issue 4, 207-207.
  6. Wu C, Yu S, L A, Li H, Sahu G, Marx P, vonLaer D, Skowron G, Shaw G, Kaur A, Junghans R, Braun S. Adoptive T cell immunotherapy using CMV-specific T cells genetically modified with anti HIV-CAR vectors. Journal of Medical Primatology (2018), 47, Issue 5, 309-310.
  7. Kaljas Y, Liu C, Skaldin M, Wu C, Zhou Q, Lu Y, Aksentijevich I, Zavialov AV. Human adenosine deaminases ADA1 and ADA2 bind to different subsets of immune cells. Cell Mol Life Sci. 2017 Feb;74(3):555-570.
  8. Varshney R, Ali Q, Wu C, Sun Z. Monocrotaline-Induced Pulmonary Hypertension Involves Downregulation of Antiaging Protein Klotho and eNOS Activity. Hypertension. 2016 Nov;68(5):1255-1263. (*: equal contribution)
  9. Chengqian LIU, Yulia Mukienko, Chengxiang Wu and Andrey Zavialov. Human adenosine deaminases control the immune cell responses to activation signals by reducing extracellular adenosine concentration. J Immunol May 1, 2016, 196 (1 Supplement) 124.63.
  10. Wu C, Liu C, Skaldin M, Lu Y, Zavialov AV. Application of ADA1 as a new marker enzyme in sandwich ELISA to study the effect of adenosine on activated monocytes. Sci Rep. 2016 6:31370. (: equal contribution)
  11. Kang W., Marasco WA, Tong HI, Byron MM, Wu C, Shi Y, Sun S, Sun Y, Lu Y. Anti-tat Hutat2:Fc mediated protection against tat-induced neurotoxicity and HIV-1 replication in human monocyte-derived macrophages. J Neuroinflammation. 2014, 11:195.
  12. Tong J, Buch S, Yao H, Wu C, Tong HI, Wang Y, Lu Y. 2014. Monocytes-derived macrophages mediated stable expression of human brain-derived neurotrophic factor, a novel therapeutic strategy for NeuroAIDS. Plos One 9(2):e82030.
  13. Wu C, Nerurkar VR, and Lu Y. 2013. New insights into the inhibition of human immunodeficiency virus type 1 replication through mutant tRNALys3. Retrovirology 10(1):112.
  14. Wu C and Y Lu. 2012. HIV treatment: mechanisms of neurotoxicity and implications for targeted therapy. Neurobehav HIV Med 4:75-98.
  15. Wu C, Cao S, Maggirwar S, Dewhurst S, Lu Y. 2012. Construction and characterization of lentiviral vector-mediated expression of TNFR as a potential protective molecule in human neuronal cells. J Neuroimmune Pharmacol 7(Suppl 1):S60.
  16. Wu C,* Cao S,* Yang Y, Sniderhan LF, Maggirwar S, Dewhurst S, and Lu Y. 2011. Lentiviral vector-mediated stable expression of sTNFR-Fc in human macrophage and neuronal cells as a potential therapy for neuroAIDS. J Neuroinflamation. 8: 48. (*: equal contribution)
  17. Leng Y, Wu C, Liu Z, Friesen TL, Rasmussen JB, Zhong S. 2011. RNA-mediated gene silencing in the cereal fungal pathogen Cochliobolus sativus. Mol Plant Pathol 12(3): 289-298.
  18. Wu C and Lu Y. 2010. High-titer retroviral vector system for efficient gene delivery into human and mouse cells of haematopoietic and lymphocytic lineages. J Gen Virol 91: 1909-1918.
  19. Asahina AY, Lu Y, Wu C, Fujioka RS and Loh PC. 2009. Potential biosentinels of human waste in marine coastal waters: Bioaccumulation of human caliciviruses and enteroviruses from sewage polluted waters by indigenous mollusks. J Virol Methods 158: 46–50.
  20. Wu C, Nerurkar VR, Yanagihara R, and Lu Y. 2008. Effective modifications for improved homologous recombination and high-efficiency generation of recombinant adenovirus-based vectors. J Virol Methods 153(2):120-128.
  21. Yang Y, Wu C, Wu J, Nerurkar VR, Yanagihara R, Lu Y. 2008. Inhibition of West Nile Virus replication by retrovirus-delivered small interfering RNA in human neuroblastoma cells. J Med Virol 80(5):930-936.
  22. Wu C and Lu Y. 2007. Inclusion of high molecular weight dextran in calcium phosphate-mediated transfection significantly improves gene transfer efficiency. Cell Mol Biol (Noisy-le-grand). 53(4):67-74.
  23. Zeng LB, Yang SM, Wu C, Planelles V, Dewhurst S, Ye LB, and Lu Y. 2006. Effective transduction of primary mouse blood-and bone marrow-derived monocytes/macrophages by HIV-1-based defective lentiviral vectors. J Virol Methods 134:66-73.
  24. Wu C, Wan Y, Xu J, Su J, and Fang X. 2002. Establishment of a new rice transformation system by regeneration from embryonic callus induced from scutum of mature embryo. Chinese Journal of Tropical Crops 23(3): 88-94. (in Chinese)
  25. Wu C, Wan Y, Xu J, Su J, and Fang X. 2002. Analysis of matrix attachment region (MAR)-mediated transgene expression in transgenic rice generated by gene bombardment transformation method. Journal of Agricultural Biotechnology 10(3): 227-230. (in Chinese)
  26. Su J, Zhu R, Wu C, Fang X. 2000. Cloning and functional characterization of the chloroplast Glutamine synthetase cDNA from Pisum Sativum. Journal of Agricultural Biotechnology 4(8): 326-330. (in Chinese)


Profile Details

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