Biography

Dr. Guozheng Wang

Institute of Infection, Veterinary & Ecological Sciences
Faculty of Health and Life Sciences

University of Liverpool, UK


Email: wangg@liv.ac.uk, G.Wang@liverpool.ac.uk


Qualifications

1998-2002 Ph.D., University of Liverpool, Liverpool, UK

1985-1988 M.D., Southeast University, Nanjing, China

1977-1982 MBChB., Southeast University, Nanjing, China


Publications (Selected)

  1. Toh, J. M., Yong, J., Abrams, S. T., Wang, L., Schofield, J., Lane, S., ... & Wang, G. (2024). Fibrinogen binding to histones in circulation protects against adverse cellular and clinical outcomes. Journal of Thrombosis and Haemostasis.
  2. Abrams, S. T., Du, M., Shaw, R. J., Johnson, C., McGuinness, D., Schofield, J., ... & Wang, G. (2024). Damage-associated cellular markers in the clinical and pathogenic profile of vaccine-induced immune thrombotic thrombocytopenia. Journal of Thrombosis and Haemostasis, 22(4), 1145-1153.
  3. Ismail, T. M., Crick, R. G., Du, M., Shivkumar, U., Carnell, A., Barraclough, R., ... & Wang, G. (2023). Targeted Destruction of S100A4 Inhibits Metastasis of Triple Negative Breast Cancer Cells. Biomolecules, 13(7), 1099.
  4. Abrams, S. T., Alhamdi, Y., Zi, M., Guo, F., Du, M., Wang, G., ... & Toh, C. H. (2023). Extracellular Histone-Induced Protein Kinase C Alpha Activation and Troponin Phosphorylation Is a Potential Mechanism of Cardiac Contractility Depression in Sepsis. International Journal of Molecular Sciences, 24(4), 3225.
  5. Abrams, S. T., Wang, L., Yong, J., Yu, Q., Du, M., Alhamdi, Y., ... & Wang, G. (2022). The importance of pore-forming toxins in multiple organ injury and dysfunction. Biomedicines, 10(12), 3256.
  6. Alsabani, M., Abrams, S. T., Cheng, Z., Morton, B., Lane, S., Wang, G., ... & Toh, C. H. (2022). Reduction of NETosis by targeting CXCR1/2 reduces thrombosis, lung injury, and mortality in experimental human and murine sepsis. British journal of anaesthesia, 128(2), 283-293.
  7. Abrams, S. T., Su, D., Sahraoui, Y., Lin, Z., Cheng, Z., Wang, G., ... & Toh, C. H. (2021). Assembly of alternative prothrombinase by extracellular histones initiates and disseminates intravascular coagulation. Blood, The Journal of the American Society of Hematology, 137(1), 103-114.
  8. Wang, Z., Cheng, Z., Abrams, S. T., Lin, Z., Yates, E. D., Yu, Q., ... & Wang, G. (2020). Extracellular histones stimulate collagen expression and potentially promote liver fibrogenesis via TLR4-MyD88 signalling pathway. bioRxiv, 2020-09.
  9. Cheng, Z., Abrams, S. T., Austin, J., Toh, J., Wang, S. S., Wang, Z., ... & Wang, G. (2020). The central role and possible mechanisms of bacterial DNAs in sepsis development. Mediators of Inflammation, 2020(1), 7418342.
  10. Cheng, Z., Abrams, S. T., Toh, J., Wang, S. S., Wang, Z., Yu, Q., ... & Wang, G. (2020). The critical roles and mechanisms of immune cell death in sepsis. Frontiers in immunology, 11, 1918.
  11. Cheng, Z., Abrams, S. T., Toh, J., Wang, S. S., Downey, C., Ge, X., ... & Toh, C. H. (2020). Complexes between C-Reactive Protein and Very Low Density Lipoprotein Delay Bacterial Clearance in Sepsis. The Journal of Immunology, 204(10), 2712-2721.
  12. Du, M., Wang, G., Barsukov, I. L., Gross, S. R., Smith, R., & Rudland, P. S. (2020). Direct interaction of metastasis-inducing S100P protein with tubulin causes enhanced cell migration without changes in cell adhesion. Biochemical Journal, 477(6), 1159-1178.
  13. Cheng, Z., Abrams, S. T., Alhamdi, Y., Toh, J., Yu, W., Wang, G., & Toh, C. H. (2019). Circulating histones are major mediators of multiple organ dysfunction syndrome in acute critical illnesses. Critical care medicine, 47(8), e677-e684.
  14. Moxon, C. A., Alhamdi, Y., Storm, J., Toh, J. M., Ko, J. Y., Wang, G., ... & Toh, C. H. (2019). Parasite histones mediate leak and coagulopathy in cerebral malaria. bioRxiv, 563551.


Profile Details

https://orcid.org/0000-0001-5525-3548

https://www.liverpool.ac.uk/people/guozheng-wang

https://sciprofiles.com/profile/1159139

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