Dr. Hesham M. Korashy

Department of Pharmacology & Toxicology, College of Pharmacy

King Saud University, Saudi Arabia

Associate Professor for Molecular and Environmental Toxicology



2007 Ph.D., Faculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, CANADA

1997 B.S., College of Pharmacy, King Saud University, SAUDI ARABIA

Research Fields

Molecular Pharmacology

Environmental Toxicology

Cardiovascular Toxicology

Publications (selected)

  1. Al-Harbi NO, Imam F, Al-Harbi MM, Iqbal M, Nadeem A, Al-Shahrah OA, Korashy HM, Al-Hosaini KA, Ahmed M, Bahashwar S. (2014): Treatment with aliskiren ameliorates tacrolimus-induced nephrotoxicity in rats. J Renin Angiotensin Aldosterone Syst, (In press).
  2. Ashour AE, Abd-Allah AR, Korashy HM, Attia SM, Alzahrani AZ, Saquib Q, Bakheet SA, Abdel-Hamied HE, Jamal S, Rishi AK. (2014): Thymoquinone suppression of the human hepatocellular carcinoma cell growth involves inhibition of IL-8 expression, elevated levels of TRAIL receptors, oxidative stress and apoptosis. Mol Cell Biochem, 389:85-98.
  3. Maayah ZH, Mushtaq MA, El Gendy MA, Al-Arifi NA, Korashy HM (2014): Development of Cardiac Hypertrophy by Sunitinib in Vivo and in Vitro Rat Model is influenced by the Aryl Hydrocarbon Receptor Signaling Pathway. Arch Toxicol, 88:725-38.
  4. Al-Jenoobi FI, Alam MA, Alkharfy KM, Al-Suwayeh SA, Korashy HM, Al-Mohizea AM, Iqbal M, Ahad A, Raish M (2013): Pharmacokinetic interaction studies of fenugreek with CYP3A substrates cyclosporine and carbamazepine. Eur J Drug Metab Pharmacokinet, (In press).
  5. Alkharfy KM, Al-Jenoobi FI, Alam MA, Al-Mohizea AM, Al-Suwayeh SA, Korashy HM, Khan RM, Muzaffar I (2013): Lepidium Sativum but not Nigella sativa Affects Carbamazepine Disposition in an Animal Model. Drug Metab Lett, 7:47-51.
  6. Kassem MG, Ezzeldin E, Korashy HM, and Mostafa GA (2013): High-performance liquid chromatographic method for the determination of dasatinib in rabbit plasma using fluorescence detection and its application to a pharmacokinetic study. J Chromatograph B, 939:73-79.
  7. Al-Jenoobi FI, Al-Suwayeh SA, Muzaffar I, Alam MA, Al-Kharfy KM, Korashy HM, Al-Mohizea AM, Ahad A, Raish M (2013): Effects of Nigella sativa and Lepidium sativum on Cyclosporine Pharmacokinetics. Biomed Res Int, 2013:953520.
  8. Korashy HM, Abou-Hasheesh H, Maayah ZH (2.013): The Role of Aryl Hydrocarbon Receptor-Regulated Cytochrome P450 Enzymes in Glioma. Curr Pharm Des, 19:6752-6763.
  9. Al Bakheet SA, Attafi IM, Maayah ZH, Abd-Allah AR, Asiri YA, Korashy HM (2013): Effect of Long-Term Human Exposure to Environmental Heavy Metals on the Expression of Detoxification and DNA Repair Genes. Environ Poll, 181:226-232.
  10. Ansari MA, Maayah ZH, Bakheet SA, El-Kadi AO, Korashy HM (2013): The role of aryl hydrocarbon receptor signaling pathway in cardiotoxicity of acute lead intoxication in vivo and in vitro rat model. Toxicology, 5:40-49.
  11. Al-Mazroua HA, Al-Rasheed NM, and Korashy HM (2013); Down-Regulation of the Cardiotrophin-1 Gene Expression by Valsartan and Spironolactone in Hypertrophied Heart Rats in Vivo and Rat Cardiomyocyte H9c2 cell Line in Vitro; A Novel Mechanism of Cardioprotection. J Cardio pharmacol, 6:337-344 12.
  12. Maayah ZH, El Gendy MA, El-Kadi AO, Korashy HM (2013): Sunitinib, a tyrosine kinase inhibitor, induces cytochrome P450 1A1 gene in human breast cancer MCF7 cells through ligand-independent aryl hydrocarbon receptor activation. Arch Toxicol, 87:847-856.
  13. Al-Arifi MN, Maayah ZH, and Korashy HM (2012): Impact of Cigarette Smoke Exposure on the Expression of Cardiac Hypertrophic Genes, Cytochrome P450 enzymes, and Oxidative Stress Markers in Rats. J Toxicol Sci, 37:1083-1090.
  14. Ashour AE, Alhaider AA, Sayed-Ahmed MM, Korashy HM, Maayah ZH, Alkhalidi H, Mubarak M, and Abd-Allah AR (2012): Metformin rescues the myocardium from doxorubicin-induced energy starvation and mitochondrial damage in Rats. Oxid Med Cell Longev, 2012:434195.
  15. Korashy HM, Maayah ZH, Abd-Allah AR, El-Kadi AO, and Alhaider AA (2012): Camel Milk Triggers Apoptotic Signaling Pathways in Human Hepatoma HepG2 and Breast Cancer MCF7 Cell Lines through Transcriptional Mechanisms. J Biomed Biotechnol, 2012:593195.
  16. Kassem MG, Rahman AF, Korashy HM (2012): Sunitinib Malate: Comprehensive Profile. Profiles of Drug Substances, Excipients and Related Methodology, 37:363-388.
  17. Korashy HM, El Gendy MA, Alhaider AA, and El-Kadi AO (2012): Camel Milk Modulates the Expression of Aryl Hydrocarbon Receptor- Regulated Genes, Cyp1a1, Nqo1, and Gst1a2, in Murine hepatoma Hepa 1c1c7 Cells. J Biomed Biotechnol, 2012:78264.
  18. Korashy HM, and El-Kadi AO (2012): Transcriptional and Posttranslational Mechanisms Modulating the Expression of the Cytochrome P450 1A1 Gene by Lead in HepG2 Cells: A Role for Heme Oxygenase. Toxicology, 291:113-121.
  19. Korashy HM, Anwar-Mohamed A, Soshilov AA, Denison MS, El-Kadi AO. (2011): The p38 MAPK Inhibitor SB203580 Induces Cytochrome P450 1A1 Gene Expression in Murine and Human Hepatoma Cell Lines through Ligand-Dependent Aryl Hydrocarbon Receptor Activation. Chem Res Toxicol, 24:1540-1548.
  20. Alhaider AA, Korashy HM, Sayed-Ahmed MM, Mobark M, Kfoury H, Mansour MA (2011). Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through modulation of oxidative stress genes expression. Chem Biol Interact, 192:233-242.
  21. Bakheet SA, Attia SM, Al-Rasheed NM, Al-Harbi MM, Ashour AE, Korashy HM, Abd-Allah AR, Saquib Q, Al-Khedhairy AA, Musarrat (2011). Salubrious effects of dexrazoxane against teniposide-induced DNA damage and programmed cell death in murine marrow cells. J.Mutagenesis, 26:533-543.
  22. Ashour AE, Abdel-Hamied HE, Korashy HM, Al-Shabanah OA, Abd-Allah AR (2011). Alpha-Lipoic Acid Rebalances Redox and Immune-Testicular Milieu in Septic Rats. Chem Biol Interact, 189:198-205.
  23. Alhaider AA, El-Gendy, Korashy HM, and El-Kadi AO (2011). Camel urine inhibits the cytochrome P450 1a1 gene expression through an AhR-dependent mechanism in Hepa 1c1c7 cell line. J Ethnopharmacol. 133:184-190.
  24. Patel JP, Korashy HM, El-Kadi AO, Brocks DR.(2009) Effect of bile and lipids on the stereoselective metabolism of halofantrine by rat everted-intestinal sacs. Chirality, 22: 275-283.
  25. Shayeganpour A, Korashy HM, Patel JP, El-Kadi AO, Brocks DR (2008): The impact of experimental hyperlipidemia on the distribution and metabolism of amiodarone in rat. Int J Pharm, 361:78-86.

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