Dr. Zhiwei Hu

College of Medicine Ohio State University, USA

Associate Professor

Email: zhiwei.hu.2011@gmail.com

Qualifications

1997  Ph.D., Tumor Immunobiology, Hunan Medical University, China

1994  M.S., Tumor Immunology, Jiangxi Medical College, China

1991  M.D., Medicine and Stomatology, Jiangxi Medical College, China

Publications(Selected)

1. Zhiwei Hu. (2012) Dual targeting of tumor neovasculature and tumor cells by tissue factor-targeted photodynamic therapy. Journal of Analytical & Bioanalytical Techniques. 3:e15.doi.10.4172/2155-9872.1000e105
2. Zhiwei Hu. (2011) Factor VII-Targeted Photodynamic Therapy for Breast Cancer and Its Therapeutic Potential for Other Solid Cancers and Leukemia. Breast Cancer - Current and Alternative Therapeutic Modalities. Esra Gunduz and Mehmet Gunduz (Ed.), ISBN: 978-953-307-776-5, InTech. Pages 175-196
3. Available from: http://www.intechopen.com/articles/show/title/factor-vii-targeted-photodynamic-therapy-for-breast-cancer-and-its-therapeutic-potential-for-other-s
4. Jijun Cheng, Jie Xu, Jinzhong Duanmu, Han Zhou, Carmen J. Booth and Zhiwei Hu. (2011) Effective treatment of human lung cancer by targeting tissue factor with a factor VII-targeted photodynamic therapy. Current Cancer Drug Targets. 11(9): 1069-1081
5. Jinzhong Duanmu, Jijun Cheng, Jie Xu, Carmen J. Booth and Zhiwei Hu. (2011) Effective treatment of chemoresistant breast cancer in vitro and in vivo by a factor VII-targeted photodynamic therapy. British Journal of Cancer. 104(9): 1401-1409.
6. Zhiwei Hu, Benqiang Rao, Shimin Chen and Jinzhong Duanmu. (2011) Selective and effective killing of angiogenic vascular endothelial cells and cancer cells by targeting tissue factor using a factor VII-targeted photodynamic therapy for breast cancer. Breast Cancer Research and Treatment. 126(3):589-600
7. Zhiwei Hu and Jing Li (2010). Natural killer cells are crucial for the efficacy of Icon (factor VII/human IgG1 Fc) immunotherapy in human tongue cancer. BMC Immunology. 2010, 11(1):49 This article has been labeled as “Highly Accessed” since its publication and is publicly available at http://www.ncbi.nlm.nih.gov/pubmed/20939894
8. Zhiwei Hu, Benqiang Rao, Shimin Chen and Jinzhong Duanmu. (2010) Targeting tissue factor on tumour cells and angiogenic vascular endothelial cells by factor VII-targeted verteporfin photodynamic therapy for breast cancer in vitro and in vivo in mice. BMC Cancer. 2010, 10:235 This article is publicly available at
   http://www.ncbi.nlm.nih.gov/pubmed/20504328
9. Graciela Krikun, Zhiwei Hu, Kevin Osteen, Kaylon Tran-Brunner, Frederick Schatz, Hugh S. Taylor, Paolo Toti, Felice Arcuri, William Konigsberg, Alan Garen, Carmen J. Booth, and Charles J. Lockwood. (2010) Targeting Tissue Factor with the Immunoconjugate “Icon” Leads To the Regression of Endometriosis Through Destruction of Aberrant Blood Vessels. American Journal of Pathology 176(2):1050-1056
10. Fang Lu, Zhiwei Hu, John Sinard, Alan Garen, and Ron A Adelman. (2009) Factor VII–verteporfin for Targeted Photodynamic Therapy in a Rat Model of Choroidal Neovascularization. Investigative Ophthalmology & Visual Science. 50(8): 3890-6.
11. Puran S. Bora, Zhiwei Hu, Tongalp H. Tezel, Jeong- Hyeon Sohn, Shin Goo Kang, Jose M. Cruz, Nalini S. Bora, Alan Garen and Henry J. Kaplan. (2003) Immunotherapy for choroidal neovascularization in a laser-induced mouse model simulating exudative (wet) macular degeneration. Proc. Natl. Acad. Sci. USA. 100: 2679-2684
12. Zhiwei Hu. (2002) Antigen-driven stimulation of B-lymphocytes in vitro. In O’Brian, P.M and Aitken, R., ed., Methods in Molecular Biology, Volume 178: Antibody Phage Display: Methods and Protocols. The Humana Press Inc., New Jersey, USA. p 113-119
13. Zhiwei Hu and Alan Garen. (2001) Targeting tissue factor on tumor vascular endothelial cells and tumor cells for immunotherapy in mouse models of prostatic cancer. Proc. Natl. Acad. Sci. USA. 98:12180-12185
14. Zhiwei Hu and Alan Garen. (2000) Intratumoral injection of adenoviral vectors encoding tumor-targeted immunoconjugates for cancer immunotherapy. Proc. Natl. Acad. Sci. USA. 97: 9221-9225
15. Zhiwei Hu, Ying Sun and Alan Garen. (1999) Targeting tumor vasculature endothelial cells and tumor cells for immunotherapy of human melanoma in a mouse xenograft model. Proc. Natl. Acad. Sci. USA. 96: 8161-8166

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